Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease (Retracted article. See vol. 76, pg. 1915, 2020)
Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease (Retracted article. See vol. 76, pg. 1915, 2020)
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DOI：
10.1016/j.jacc.2017.11.071
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发表时间：
2018-03-06
影响因子：
24
通讯作者：
Ferreira, Vanessa M.
中科院分区：
文献类型：
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作者：
Liu, Alexander;Wijesurendra, Rohan S.;Ferreira, Vanessa M.
背景新的心脏磁共振（CMR）应力T1标测可以在没有造影剂的情况下检测缺血和心肌血容量变化，并且可能是比心肌血流量更全面的缺血生物标志物。由血流储备分数定义（FFR = 0.8和微循环阻力指数（IMR >= 25 U），与首过灌注成像相比。心绞痛60例; 30名健康对照受试者）接受CMR（1.5-和3-T）以评估左心室功能（电影）、缺血（腺苷负荷/静息T1标测和灌注）和梗死（晚期钆增强）。评估了FFR和IMR
BACKGROUND Novel cardiac magnetic resonance (CMR) stress T1 mapping can detect ischemia and myocardial blood volume changes without contrast agents and may be a more comprehensive ischemia biomarker than myocardial blood flow.OBJECTIVES This study describes the performance of the first prospective validation of stress T1 mapping against invasive coronary measurements for detecting obstructive epicardial coronary artery disease (CAD), defined by fractional flow reserve (FFR = 0.8 and the index of microcirculatory resistance (IMR >= 25 U), compared with first-pass perfusion imaging.METHODS Ninety subjects (60 patients with angina; 30 healthy control subjects) underwent CMR (1.5- and 3-T) to assess left ventricular function (cine), ischemia (adenosine stress/rest T1 mapping and perfusion), and infarction (late gadolinium enhancement). FFR and IMR were assessed