NERVE GROWTH-FACTOR TREATMENT AFTER BRAIN INJURY PREVENTS NEURONAL DEATH
NERVE GROWTH-FACTOR TREATMENT AFTER BRAIN INJURY PREVENTS NEURONAL DEATH
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DOI：
10.1126/science.3798108
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发表时间：
1987-01-09
期刊：
影响因子：
56.9
通讯作者：
KROMER, LF
中科院分区：
文献类型：
--
作者：
KROMER, LF
胆碱能神经元变性轴突切断后已提出是由于损失的逆行运输的神经营养因子，可能是神经生长因子（NGF）。为了验证这一假设，神经生长因子连续注入侧脑室的成年大鼠已收到双边病变的所有胆碱能轴突从内侧隔到背侧海马。2周的神经生长因子治疗后，胆碱能神经元的生物合成酶胆碱乙酰转移酶的存在下，识别显示了一个显着增加（350%）的轴突切断隔胆碱能神经元的生存。因此，神经生长因子或神经生长因子样分子可以作为这些神经元的神经营养因子。
Cholinergic neuronal degeneration after axotomy has been proposed to be due to the loss of a retrogradely transported neurotrophic factor, possibly nerve growth factor (NGF). To test this hypothesis, NGF was continuously infused into the lateral ventricles of adult rats that had received bilateral lesions of all cholinergic axons projecting from the medial septum to the dorsal hippocampus. After 2 weeks of NGF treatment, identification of cholinergic neurons by the presence of the biosynthetic enzyme choline acetyltransferase revealed a dramatic increase (350%) in the the survival of the axotomized septal cholinergic neurons. Thus, NGF or an NGF-like molecule can act as a neurotrophic factor for these neurons.