Sentinel lymph node imaging using quantum dots in mouse tumor models
Sentinel lymph node imaging using quantum dots in mouse tumor models
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DOI：
10.1021/bc060261j
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发表时间：
2007-03-01
影响因子：
4.7
通讯作者：
Bruchez, Marcel P.
中科院分区：
文献类型：
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作者：
Ballou, Byron;Ernst, Lauren A.;Bruchez, Marcel P.
我们证明，注射到两个模型肿瘤中的量子点可以快速迁移到前哨淋巴结。具有末端羧基、氨基或甲氧基的PEG涂覆的量子点都类似地从肿瘤迁移到周围的淋巴结。可以通过皮肤动态地观察到从肿瘤通过淋巴管到邻近淋巴结的通道；通常可以定义至少两个节点。尸检过程中的成像证实了量子点仅限于淋巴系统，并证明可以轻松标记前哨淋巴结进行病理学标记。对量子点定位识别的前哨节点的检查表明，至少有一些节点含有转移性肿瘤病灶。
We demonstrate that quantum dots injected into two model tumors rapidly migrate to sentinel lymph nodes. PEG-coated quantum dots having terminal carboxyl, amino, or methoxyl groups all migrated from the tumor to surrounding lymph nodes similarly. Passage from the tumor through lymphatics to adjacent nodes could be visualized dynamically through the skin; at least two nodes could usually be defined. Imaging during necropsy confirmed confinement of the quantum dots to the lymphatic system and demonstrated easy tagging of sentinel lymph nodes for pathology. Examination of the sentinel nodes identified by quantum dot localization showed that at least some contained metastatic tumor foci.