31P NMR studies of resting muscle in normal human subjects.
31P NMR studies of resting muscle in normal human subjects.
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正常人类受试者静息肌肉的 31P NMR 研究。
DOI：
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发表时间：
1984
影响因子：
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通讯作者：
D. Shaw
中科院分区：
文献类型：
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作者：
D. Wilkie;M. Dawson;R. Edwards;R. Gordon;D. Shaw
使用31 P局部磁共振研究人体组织是完全无创的;它允许同时测量许多重要代谢物的浓度和细胞内pH值。在某些关键情况下，TMR产生比组织活检的化学分析获得的结果更准确的结果。我们已经表明，TMR可以被校准，以获得定量测量人类受试者。我们还表明，基于限速酶的关键代谢物调节的糖酵解控制理论与在完整肌肉中观察到的变化不一致。
Study of human tissues using 31P topical Magnetic Resonance is completely atraumatic; it allows simultaneous measurement of the concentrations of many important metabolites and of intracellular pH. In some critical situations, TMR yields more accurate results than those obtained by chemical analysis of tissue biopsies. We have shown that TMR can be calibrated to obtain quantitative measurements in human subjects. We have also shown that theories of control of glycolysis based on regulation by key metabolites of rate-limiting enzymes are inconsistent with the observed changes in intact muscle.