Adrenergic stimulation decreases osteoblast oxytocin synthesis.
Adrenergic stimulation decreases osteoblast oxytocin synthesis.
复制标题
肾上腺素能刺激会减少成骨细胞催产素的合成。
DOI：
10.1111/j.1749-6632.2011.06235.x
复制
发表时间：
2011
影响因子：
5.2
通讯作者：
Zallone,Alberta
中科院分区：
文献类型：
--
作者：
Cuscito,Concetta;Colaianni,Graziana;Tamma,Roberto;Greco,Giovanni;Dell'Endice,Stefania;Yuen,Tony;Sun,Li;Zaidi,Mone;DiBenedetto,Adriana;Zallone,Alberta
Oxytocin (OT) regulates bone mass by inducing the differentiation of osteoblasts to a mature, mineralizing phenotype. We have shown recently that osteoblasts can synthesize OT. In view of known interactions between OT‐ergic and adrenergic neurons in the central nervous system, we questioned whether the negative regulation of osteoblast differentiation by adrenergic nerves was mediated through its suppression of OT synthesis. We first confirmed that α1band β2adrenergic receptors were expressed on both primary murine osteoblasts and MC3T3‐E1 cells. We then showed that α1and β2adrenergic agonists downregulated OT synthesis, and that the effect of each agonist was reversed by its respective antagonist. The data suggest that the negative effects of adrenergic stimulation on bone mass could, in part, arise from decreased OT synthesis.
