Hepatic Metastasis from Colorectal Cancer.
Hepatic Metastasis from Colorectal Cancer.
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DOI：
10.5005/jp-journals-10018-1241
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发表时间：
2017-07
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影响因子：
--
通讯作者：
Montalvo-Javé EE
中科院分区：
文献类型：
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作者：
Valderrama-Treviño AI;Barrera-Mera B;Ceballos-Villalva JC;Montalvo-Javé EE
肝脏是结直肠癌患者中最常见的转移部位，因为其门静脉循环的解剖位置。约14 - 18%的结直肠癌患者在首次就诊时出现转移，10 - 25%的患者在原发结直肠癌切除时出现转移。当使用计算机断层扫描（CT）时，发病率更高（35%）。在过去的几十年里，通过不同的诊断和治疗方案，结直肠癌患者的预期寿命显著延长。尽管有这些改善，但转移、疾病复发和晚期局部肿瘤的存在仍然是不良预后因素。不经治疗的中位生存期自发病起<8个月，而对于出现局部转移的患者，5年生存率为11%是最佳预后。即使在转移性疾病有限的患者中，5年生存率也非常高。结直肠癌肝转移患者不接受治疗的中位生存期为5至20个月。大约20%至30%的结直肠转移患者的疾病局限于肝脏，这可以通过手术治疗。主要肝胆中心的现代手术策略已经证明，可以切除70%的肝脏，死亡率<5%。了解肝转移的易感因素、诊断方法和治疗是非常重要的。然而，为早期诊断和适当治疗建立更新、有效的预防性筛查项目是至关重要的。如何引用本文：Valderrama-Treviño AI， Barrera-Mera B, Ceballos-Villalva JC, montalvo - jav<s:1> EE。结直肠癌的肝转移。中华肝病杂志，2017;7(2):166-175。
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs. Despite these improvements, the presence of metastasis, disease recurrence, and advanced local tumors continue to remain poor prognostic factors. Median survival without treatment is <8 months from the moment of its presentation, and a survival rate at 5 years of 11% is the best prognosis for those who present with local metastasis. Even in patients with limited metastatic disease, 5-year survival is exceptional. Patients with hepatic metastasis of colorectal cancer have a median survival of 5 to 20 months with no treatment. Approximately 20 to 30% of patients with colorectal metastasis have disease confined to the liver, and this can be managed with surgery. Modern surgical strategies at the main hepatobiliary centers have proved that hepatectomy of 70% of the liver can be performed, with a mortality rate of <5%. It is very important to have knowledge of predisposing factors, diagnostic methods, and treatment of hepatic metastasis. However, the establishment of newer, efficient, preventive screening programs for early diagnosis and adequate treatment is vital. How to cite this article: Valderrama-Treviño AI, Barrera-Mera B, Ceballos-Villalva JC, Montalvo-Javé EE. Hepatic Metastasis from Colorectal Cancer. Euroasian J Hepato-Gastroenterol 2017;7(2):166-175.