Lithium: Clinical considerations in internal medicine
Lithium: Clinical considerations in internal medicine
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DOI：
10.1016/j.amjmed.2005.11.003
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发表时间：
2006-06-01
影响因子：
5.9
通讯作者：
Freeman, Scott A.
中科院分区：
文献类型：
--
作者：
Freeman, Marlene P.;Freeman, Scott A.
双相情感障碍影响多达5%的人口。虽然治疗双相情感障碍的药物选择在过去几年中已经扩大，但锂仍然是一种廉价而有效的治疗双相情感障碍的药物。锂已被证明是一种有效的治疗急性躁狂，双相抑郁症，双相情感障碍的预防性治疗，并作为一种增强剂在治疗单极重性抑郁症。锂也是唯一一种被证明可以降低双相情感障碍患者自杀率的情绪稳定剂。讨论了特殊人群的使用、副作用和毒性以及药物相互作用。本综述包括重要的实验室监测指南。锂仍然是治疗情绪障碍的重要干预手段。(c) 2006爱思唯尔公司版权所有。
Bipolar Disorders affect up to 5% of the population. While the pharmacological options for the treatment of bipolar disorder have expanded over the past several years, lithium remains an inexpensive and efficacious treatment for bipolar disorder. Lithium has been demonstrated to be an effective treatment for acute mania, bipolar depression, the prophylactic treatment of bipolar disorder, and as an augmentation agent in the treatment of unipolar major depression. Lithium also is the only mood stabilizer that has been demonstrated to lower the suicide rate in patients with bipolar disorder. Use in special populations, side effects and toxicity, and drug interactions are discussed. Important laboratory monitoring guidelines are included in this review. Lithium remains an important intervention for the treatment of mood disorders. (c) 2006 Elsevier Inc. All rights reserved.