The ''cyclic'' regimen of low-dose doxycycline for adult periodontitis: A preliminary study
The ''cyclic'' regimen of low-dose doxycycline for adult periodontitis: A preliminary study
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DOI：
10.1902/jop.1996.67.5.506
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发表时间：
1996-05-01
影响因子：
4.3
通讯作者：
Golub, LM
中科院分区：
文献类型：
--
作者：
Crout, RJ;Lee, HM;Golub, LM
在短期研究中，已发现特殊配方的低剂量强力霉素（LDD）方案可降低成人牙周炎受试者牙龈组织和龈沟液（GCF）中的胶原酶活性。在目前的双盲、安慰剂对照研究中，成年牙周炎患者接受为期6个月的LDD或安慰剂胶囊的“周期性”治疗方案;在不同时间段测量牙周病严重程度的各种临床参数，以及GCF中胶原酶活性和血清蛋白α（1）-PI的降解。LDD治疗组和安慰剂治疗组之间的菌斑指数和牙龈指数无显著差异。然而，附着水平、探测深度、GCF胶原酶活性和α（1）-PI降解均受到药物方案的有益和显著影响（P < 0.05）。我们建议：1）LDD在缺乏抗菌或显著抗炎功效的情况下抑制组织破坏;和2）长期LDD可能是治疗成人牙周炎患者的器械治疗的有用辅助手段。
SPECIALLY-FORMULATED LOW-DOSE DOXYCYCLINE (LDD) regimens have been found to reduce collagenase activity in the gingival tissues and crevicular fluid (GCF) of adult periodontitis subjects in short-term studies. In the current, double-blind, placebo-controlled study, adult periodontitis patients were administered for 6 months a ''cyclical'' regimen of either LDD or placebo capsules; and various clinical parameters of periodontal disease severity, and both collagenase activity and degradation of the serum protein, alpha(1)-PI, in the GCF were measured at different time periods. No significant differences between the LDD- and placebo-treated groups were observed for plaque index and gingival index. However, attachment levels, probing depth, and GCF collagenase activity and alpha(1)-PI degradation were all beneficially and significantly (P < 0.05) affected by the drug regimen. We propose: 1) that LDD inhibits tissue destruction in the absence of either antimicrobial or significant anti-inflammatory efficacy; and 2) that long-term LDD could be a useful adjunct to instrumentation therapy in the management of the adult periodontitis patient.