Mechanisms of thyroid hormone action
Mechanisms of thyroid hormone action
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DOI：
10.1172/jci60047
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发表时间：
2012-09-01
影响因子：
15.9
通讯作者：
Brent, Gregory A.
中科院分区：
文献类型：
--
作者：
Brent, Gregory A.
我们对甲状腺激素作用的理解已经被最近在激素抵抗综合征和广泛的条件下甲状腺信号传导缺陷的临床观察所改变，包括严重的精神发育迟滞，肥胖，代谢紊乱和一些癌症。甲状腺激素作用的机制已经被这些临床观察以及动物模型所告知，并影响了我们看待局部配体可用性的作用的方式;组织和细胞特异性甲状腺激素转运蛋白，辅抑制因子和辅激活因子;甲状腺激素受体（TR）亚型特异性作用;以及代谢调节和神经发育中的串扰。在某些情况下，我们的新认识已经转化为治疗策略，特别是治疗高脂血症和肥胖症，其他药物正在开发中，用于治疗心脏病和癌症，并改善认知功能。
Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including profound mental retardation, obesity, metabolic disorders, and a number of cancers. The mechanism of thyroid hormone action has been informed by these clinical observations as well as by animal models and has influenced the way we view the role of local ligand availability; tissue and cell-specific thyroid hormone transporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform-specific action; and cross-talk in metabolic regulation and neural development. In some cases, our new understanding has already been translated into therapeutic strategies, especially for treating hyperlipidemia and obesity, and other drugs are in development to treat cardiac disease and cancer and to improve cognitive function.