Gender determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with borderline personality disorder
Gender determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with borderline personality disorder
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DOI：
10.1016/j.psychres.2015.04.008
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发表时间：
2015-07-30
影响因子：
11.3
通讯作者：
Akiyoshi, Jotaro
中科院分区：
文献类型：
--
作者：
Inoue, Ayako;Oshita, Harumi;Akiyoshi, Jotaro
边缘型人格障碍（BPD）以情感不稳定、人际关系不稳定和身份障碍为特征。我们测量了所有参与者在接受特里尔社会压力测试（TSST）和电刺激应激时唾液α -淀粉酶（sAA）和唾液皮质醇水平。72名BPD患者与377名年龄和性别匹配的对照组进行了比较。在电刺激前对被试进行状态版和特质版的斯皮尔伯格焦虑量表（STAI-S和STAI-T）、情绪状态量表（POMS）、贝克抑郁量表（BDI）和抑郁与焦虑认知量表（DACS）。与对照组相比，暴露于TSST后，女性患者唾液皮质醇水平显著降低，男性患者唾液皮质醇水平显著升高。与对照组相比，BPD患者的POMS紧张-焦虑、抑郁-沮丧、愤怒-敌意、疲劳和困惑得分显著增加。相比之下，BPD患者的活力评分明显低于对照组。此外，与对照组相比，BPD患者的STAI-T、STAI-S焦虑评分和BDI评分均显著升高。与对照组相比，BPD患者的DACS评分明显升高。不同的应激源（如心理或生理）在女性和男性BPD患者的HPA和SAM系统中引起不同的反应。2015爱思唯尔爱尔兰有限公司版权所有。
Borderline personality disorder (BPD) is characterized by affective instability, unstable relationships, and identity disturbance. We measured salivary alpha-amylase (sAA) and salivary cortisol levels in all participants during exposure to the Trier Social Stress Test (TSST) and an electric stimulation stress. Seventy-two BPD patients were compared with 377 age- and gender- matched controls. The State and Trait versions of the Spielberger Anxiety Inventory test (STAI-S and STAI-T, respectively), the Profile of Mood State (POMS) tests, and the Beck Depression Inventory (BDI), the Depression and Anxiety Cognition Scale (DACS) were administered to participants before electrical stimulation. Following TSST exposure, salivary cortisol levels significantly decreased in female patients and significantly increased in male patients compared with controls. POMS tension-anxiety, depression-dejection, anger-hostility, fatigue, and confusion scores were significantly increased in BPD patients compared with controls. In contrast, vigor scores were significantly decreased in BPD patients relative to controls. Furthermore, STAI-T and STAI-S anxiety scores and BDI scores were significantly increased in BPD patient compared with controls. DACS scores were significantly increased in BPD patient compared with controls. Different stressors (e.g., psychological or physical) induced different responses in the HPA and SAM systems in female or male BPD patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.