Reverse Turns in Peptides and Protein
Reverse Turns in Peptides and Protein
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DOI：
10.3109/10409238009105470
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
John A. Smith;L. G. Pease;K. Kopple
中科院分区：
文献类型：
--
作者：
John A. Smith;L. G. Pease;K. Kopple
反转经常作为蛋白质以及线性和环状肽的结构组分发生的证据是压倒性的。这篇评论总结并严格审查来自物理方法，如1H和13 C核磁共振光谱，自旋晶格弛豫时间，圆二色性，红外光谱和X射线晶体学的实验证据。其次，从能量计算中获得的理论证据，它依赖于经验能量函数，和相关的方法，它依赖于算法的基础上出现的氨基酸的频率，进行评估。特别是，那些补充物理研究已经完成的理论研究强调。最后，结构与功能的关系，包括反向转动和它们的生物识别的例子进行了演示。
The evidence that reverse turns frequently occur as structural components of proteins, as well as of linear and cyclic peptides, is overwhelming. This review summarizes and examines critically the experimental evidence derived from physical methods such as 1H and 13C nuclear magnetic resonance spectroscopy, spin-lattice relaxation time, circular dichroism, IR spectroscopy, and X-ray crystallography. Secondly, theoretical evidence obtained from energy calculations, which rely on empirical energy functions, and correlative methods, which rely on algorithms based on the frequency of occurrence of amino acids, is evaluated. In particular, those theoretical studies for which complementary physical studies have been completed are emphasized. Finally, examples of structure-function relationships involving reverse turns and their biological recognition are demonstrated.