Studies with the radioimmunoassay for angiotensin II, and its application to measurement of renin activity.
Studies with the radioimmunoassay for angiotensin II, and its application to measurement of renin activity.
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血管紧张素II放射免疫分析的研究及其在肾素活性测定中的应用。
DOI：
10.1210/jcem-29-2-200
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
A. Purnode
中科院分区：
文献类型：
--
作者：
L. B. Page;E. Haber;A. Kimura;A. Purnode
本文介绍的血管紧张素II放射免疫测定法已作了修订、改进和简化。无钠摄入的正常人血浆血管紧张素II浓度平均为21±10μμg/ml，可用于肾素活性的测定，其平均值为0.73±0.32U/ml。正常受试者钠摄取、活动和利尿剂使用的变化会导致循环中血管紧张素和肾素活性的预期变化。肾脏病患者的循环血管紧张素缺乏，肾素活性很低，但可测得。
ABSTRACT The radioimmunoassay for angiotensin II which we previously described has been revised, improved and simplified. Plasma angiotensin II concentration in normal subjects on unrestricted sodium intake averages 21±10 μμg/ml. The method may be applied to measurement of renin activity, giving average values of 0.73±0.32 U/ml plasma in normal subjects. Variation in sodium intake, activity and the administration of diuretics in normal subjects produce expected changes in both circulating angiotensin and renin activity. Anephric subjects show absent circulating angiotensin and very low but measurable renin activities.