Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa.
Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa.
复制标题
成纤维细胞、脂蛋白和三种抗脂蛋白 IgA kappa 之间的相互作用。
DOI：
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发表时间：
1980
影响因子：
4.6
通讯作者：
J. Beaumont
中科院分区：
文献类型：
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作者：
M. Baudet;C. Dachet;J. Beaumont
人低密度脂蛋白由培养的人成纤维细胞通过特定的代谢途径代谢，这需要调节细胞内胆固醇的合成。当来自骨髓瘤、混合性高脂血症和黄瘤病患者的抗脂蛋白IgA被引入系统时，我们观察到LDL分子的蛋白质降解减少，细胞内胆固醇合成的调节消失。在同一系统中，来自患有混合性高脂血症但无黄瘤病的骨髓瘤病例的抗脂蛋白 IgA 或对照 IgG 和 IgA 处于非活性状态，并且不会改变 LDL 通路。
Human low density lipoproteins are metabolized by cultured human fibroblasts, through a specific metabolic pathway, which entails the regulation of intracellular cholesterol synthesis. When anti-lipoprotein IgA coming from patients with myeloma, mixed hyperlipidaemia and xanthomatosis were introduced into the system, we observed a decrease of the protein degradation of the LDL molecule, and a disappearance of the regulation of intracellular cholesterol synthesis. In the same system, an anti-lipoprotein IgA from a case of myeloma with mixed hyperlipidaemia, but without xanthomatosis, or control IgG and IgA were inactive and did not modify the LDL pathway.