Effects of memory consolidation on human hippocampal activity during retrieval
Effects of memory consolidation on human hippocampal activity during retrieval
复制标题
DOI：
10.1016/s0010-9452(08)70189-8
复制
发表时间：
2005-08-01
期刊：
影响因子：
3.6
通讯作者：
Henke, K
中科院分区：
文献类型：
--
作者：
Bosshardt, S;Schmidt, CF;Henke, K
日常记忆经历了从短期存储到长期存储的转变，这一过程称为记忆巩固。动物研究表明，记忆巩固需要在24小时内蛋白质合成和新的海马突触的生长。为了测试人类记忆巩固的效果，我们使用功能性磁共振成像（fMRI）（一种间接测量突触活动的方法）在学习后10分钟和24小时检查了信息检索过程中的大脑激活。学习后10 min和24 h，调整学习指令以获得可比较的检索量和检索质量。左侧海马结构表现出增强的活动，在检索期间在24小时滞后相比，检索在10分钟滞后。左前海马结构的活性在24 h滞后时与提取量和提取质量的相关性强于10 min滞后时。这表明，左前海马活动和回收成功之间的关系变得更加密切巩固的进展。人海马结构的这些fMRI结果可能与动物海马结构中突触连接在24 h内增强和生长的神经生物学结果相对应。
Day-to-day memories undergo transformation from short-term to long-term storage, a process called memory consolidation. Animal studies showed that memory consolidation requires protein synthesis and the growth of new hippocampal synapses within 24 h. To test for effects of memory consolidation in the human, we examined brain activation during the retrieval of information at 10 min and at 24 h following learning using functional magnetic resonance imaging (fMRI), an indirect measure of synaptic activity. Learning instructions were adjusted to yield a comparable retrieval quantity and retrieval quality at 10 min and 24 h after learning. The left hippocampal formation exhibited enhanced activity during the retrieval at the 24 h lag compared to the retrieval at the 10 min lag. Moreover, the activity in the left anterior hippocampal formation showed stronger correlations with retrieval quantity and retrieval quality at the 24 h lag than at the 10 min lag. This suggests that the relation between left anterior hippocampal activity and retrieval success became closer as consolidation progressed. These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h.