Cardioprotective effects of chocolate and almond consumption in healthy women
Cardioprotective effects of chocolate and almond consumption in healthy women
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DOI：
10.1016/j.nutres.2006.08.007
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发表时间：
2006-10-01
影响因子：
4.5
通讯作者：
Stote, Kim S.
中科院分区：
文献类型：
--
作者：
Kurlandsky, Sara B.;Stote, Kim S.
这项研究的主要目的是确定将黑巧克力和杏仁作为低脂饮食的一部分，对循环中的血脂和炎症标志物：细胞间黏附分子(ICAM)、血管黏附分子和高敏C反应蛋白的潜在协同或相加影响。采用为期6周的4臂平行设计；49名健康的正常胆固醇血症妇女参与研究。受试者被随机分成三组：巧克力(41g/d)、杏仁(60g/d)、巧克力加杏仁，或对照组(不加巧克力或杏仁)。所有受试者都遵循国家胆固醇教育计划治疗生活方式改变饮食。所有受试者都根据指南改善了饮食摄入量，没有受试者体重增加或减轻。6周后，血清胆固醇浓度没有变化；然而，巧克力、杏仁、巧克力和杏仁组和对照组的三酰甘油水平分别降低了约21%、13%、19%和11%(P<；0.05)。在只食用巧克力的治疗组中，循环ICAM水平显著降低10%(P=0.027)。各治疗组血管黏附分子和高敏C反应蛋白水平均未见明显变化。当两种产品同时消费时，没有观察到协同或相加效应。总而言之，作为治疗生活方式改变饮食的一部分，食用巧克力和杏仁6周对健康女性没有有害影响；所有饮食修改都改善了血清三酰甘油水平，而巧克力消费降低了循环中ICAM的水平。(C)2006 Elsevier Inc.保留所有权利。
The primary objective of this study was to identify potentially synergistic or additive effects of combining consumption of dark chocolate with almonds as part of a low-fat diet on circulating levels of serum lipids and inflammatory markers: intercellular adhesion molecule (ICAM), vascular adhesion molecule, and high-sensitivity C-reactive protein. A 6-week, 4-armed parallel design was used; 49 healthy normocholesterolemic women participated. Subjects were randomized to 1 of 3 treatments: chocolate (41 g/d), almonds (60 g/d), chocolate and almonds, or control (no chocolate or almonds). All subjects followed the National Cholesterol Education Program Therapeutic Lifestyle Changes diet. All subjects improved dietary intakes in accordance with guidelines, and no subjects gained or lost weight. Serum cholesterol concentrations showed no changes after 6 weeks; however, triacylglycerol levels were reduced by approximately 21%, 13%, 19%, and 11% (P < .05), in the chocolate, almond, chocolate and almond, and control groups, respectively. Circulating ICAM levels decreased significantly by 10% in the treatment group consuming chocolate only (P = .027). No significant changes were observed for vascular adhesion molecule and high-sensitivity C-reactive protein levels in any treatment group. No synergistic or additive effects were observed when both products were consumed. In conclusion, consumption of chocolate and almonds as part of the Therapeutic Lifestyle Changes diet for 6 weeks showed no harmful effects in healthy women; all dietary modifications improved serum triacylglycerol levels, and consumption of chocolate reduced levels of circulating ICAM. (c) 2006 Elsevier Inc. All rights reserved.