The Correlation between the Inhibition of Drug Resistance and Synergism in Streptomycin and Penicillin
The Correlation between the Inhibition of Drug Resistance and Synergism in Streptomycin and Penicillin
复制标题
链霉素与青霉素耐药抑制与协同作用的相关性
DOI：
10.1128/jb.54.3.363-370.1947
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发表时间：
1947
影响因子：
3.2
通讯作者：
L. J. Kimmelman
中科院分区：
文献类型：
--
作者：
M. Klein;L. J. Kimmelman
耐药性问题已成为链霉素治疗效果的重要限制因素(Buggs等，1946；Finland等，1946；Bondi等，1946)。我们之前已经证明，在链霉素的情况下，测试的 13 个菌株都具有自发地消除链霉素抗性变体的能力（Klein 和 Kimmelman，1946；Klein，1947）。链霉素对大量敏感细菌的破坏和少数高度耐药变体的繁殖被表明是链霉素耐药性发展的机制。 Alexander 和 Leidy (1947) 最近对流感嗜血杆菌进行了研究，获得了类似的结果。在临床上，抑制链霉素耐药性的快速发展可能需要消灭相对少量的耐药细菌，这可能通过添加低浓度的另一种药物来实现。因此，在本工作中，我们在体外研究了链霉素、青霉素和磺胺嘧啶的联合作用，并确定了这些化合物的协同作用与抑制链霉素耐药性发展之间的关系。
The problem of drug resistance has become an important limiting factor in the therapeutic efficiency of streptomycin (Buggs et al., 1946; Finland et al., 1946; Bondi et al., 1946). We have previously shown in the case of streptomycin that of 13 strains tested all had the ability to throw off, spontaneously, variants resistant to streptomycin (Klein and Kimmelman, 1946; Klein, 1947). The destruction by streptomycin of the mass of susceptible bacteria and the multiplication of the fe.w highly resistant variants was indicated to be a mechanism for the development of streptomycin resistance. Alexander and Leidy (1947), working with Hemophilus influertae, have recently obtained similar results. Clinically, the inhibition of the rapid development of streptomycin resistance may then require the destruction of a relatively small number of resistant bacteria, which might be effected by the addition of a low concentration of another drug. In the present work we have therefore studied the combined action of streptomycin, penicillin, and sulfadiazine in vitro and determined the relationship between the synergistic action of the compounds and the inhibition of the development of streptomycin resistance.