ION MEDIATED CROSSLINK DRIVEN MUCOUS SWELLING KINETICS
ION MEDIATED CROSSLINK DRIVEN MUCOUS SWELLING KINETICS
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DOI：
10.3934/dcdsb.2016030
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发表时间：
2016-08-01
影响因子：
1.2
通讯作者：
Roberts, Anthony
中科院分区：
文献类型：
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作者：
Sircar, Sarthok;Roberts, Anthony
我们使用一个实验指导的多相多物种离子凝胶模型，对健康个体(野生型或WT-粘液)与囊性纤维化(CF-粘液)感染者的粘液流变性进行了定性预测。将粘液(作为聚合物相)、水(作为溶剂相)和H+、Na+、Ca~(2+)离子的理论线性化，以研究球对称粘液凝胶的水化，并根据粘液扩散系数的实验数据进行了校准。在接近平衡时，溶液的线性化形式简化为类似于众所周知的中性凝胶动力学理论的表达式。数值研究表明，Donnan势是驱动粘液膨胀/消胀转变的主要机制。然而，囊性纤维化感染粘液的肿胀动力学改变不仅取决于肿胀介质的水电组成，还由于电解质运动的改变以及粘蛋白聚合物网络的缺陷。
We provide qualitative predictions on the rheology of mucus of healthy individuals (Wild Type or WT-mucus) versus those infected with Cystic Fibrosis (CF-mucus) using an experimentally guided, multi-phase, multi species ionic gel model. The theory which accounts for mucus (as polymer phase), water (as solvent phase) and ions, H+, Na+ and Ca2+, is linearized to study the hydration of spherically symmetric mucus gels and calibrated against the experimental data of mucus diffusivities. Near equilibrium, the linearized form of the solution reduces to an expression similar to the well known kinetic theory of neutral gels. Numerical studies reveal that the Donnan potential is the dominating mechanism driving the mucus swelling/deswelling transition. However, the altered swelling kinetics of the Cystic Fibrosis infected mucus is not merely governed by the hydroelectric composition of the swelling media, but also due to the altered movement of electrolytes as well as due to the defective properties of the mucin polymer network.