Microhomology-mediated end joining: new players join the team.
Microhomology-mediated end joining: new players join the team.
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微同源介导的末端加入：新玩家加入团队
DOI：
10.1186/s13578-017-0136-8
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发表时间：
2017
影响因子：
7.5
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Wang H;Xu X
DNA双链断裂（DSB）是细胞中最有害的DNA损伤类型，由基因组DNA的内源性和外源性攻击引起。DSB的及时、正确修复对于基因组的完整性和生存非常重要。MMEJ是DSB的易错修复机制，其依赖于断裂连接侧翼的暴露微同源序列以Ku-和连接酶IV-独立的方式固定DSB。近年来，对MMEJ机制的研究取得了重要进展。本文就近年来发现的几种MMEJ因子的生物学活性及其生物学意义作一综述。
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on exposed microhomologous sequence flanking broken junction to fix DSBs in a Ku- and ligase IV-independent manner. Recently, significant progress has been made in MMEJ mechanism study. In this review, we will summarize its biochemical activities of several newly identified MMEJ factors and their biological significance.