Cellular sources of reactive oxygen and nitrogen species. Roles in signal transcription pathways
Cellular sources of reactive oxygen and nitrogen species. Roles in signal transcription pathways
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DOI：
10.1016/s0003-4509(06)75332-9
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发表时间：
2006-11-01
影响因子：
1.3
通讯作者：
Legrand, A.
中科院分区：
文献类型：
--
作者：
Beaudeux, J. -L.;Peynet, J.;Legrand, A.
关于活性氧和氮物种(ROS/RNS)的研究历史大约有50年。ROS最初被证明是由于它们对DNA和蛋白质等大分子的有害影响，导致细胞功能作为氧化应激而恶化。另一方面，最近的研究表明，ROS/RNS在细胞中作为氧化信号，导致各种基因的表达。本文综述了ERO/ERN的主要细胞来源，如线粒体呼吸链、NAD(P)H氧化酶和一氧化氮合酶，并描述了两条主要信号转导通路--核因子-KB和AP-1通路的活性物种对ERN的调节作用。
The history of studies regarding reactive oxygen and nitrogen species (ROS/RNS) is approximatively of 50 years. ROS were shown initially for their deleterious effects on marcormolecules such as DNA and proteins, leading to deterioration of cellular functions as an oxidative stress. On the other hand, recent studies have demonstrated that ROS/RNS act as oxidative signalling in cells, resulting in various gene expressions. This brief review focuses on the main cellular origins of ERO/ERN, such as mitochondrial respiratory chain, NAD(P)H oxidase and NO synthases, and describe the modulation by the reactive species of two major signal transduction pathways, NF-KB and AP-1 pathways.