Stem Cell-Based Immunomodulation After Stroke: Effects on Brain Repair Processes.
Stem Cell-Based Immunomodulation After Stroke: Effects on Brain Repair Processes.
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DOI：
10.1161/strokeaha.117.020465
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发表时间：
2018-06
期刊：
影响因子：
8.3
通讯作者：
Steinberg GK
中科院分区：
文献类型：
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作者：
Boshuizen MCS;Steinberg GK
2卒中2018年6月脑回卒中后1d，YM-1(几丁质酶样3)、胰岛素生长因子-1和Galectin-3的M2蛋白表达增加，这与神经功能恢复的改善有关。后来的一项研究表明，骨髓间充质干细胞移植到中风大鼠的侧脑室，通过增加IL-10和降低脑组织中肿瘤坏死因子的表达，减少了脑梗塞体积，促进了功能恢复。16这些M2极化作用已经在几项实验性中风研究中得到证实，这些研究都与改善神经功能有关。因此，观察到的干细胞的有益作用可能部分是因为小胶质细胞/巨噬细胞向神经保护和神经再生表型倾斜(表)。
2 Stroke June 2018 gyrus at 1-day poststroke, M2 protein expression of YM-1 (chitinase-like 3), insulin growth factor-1, and galectin-3 was increased which correlated with improved neurological recovery. A later study suggested that MSC transplantation into the lateral ventricle of stroked rats decreased infarct volume and increased functional recovery by increasing IL-10 and decreasing TNF expression in the brain. 16 These M2-polarizing actions have been confirmed in several experimental stroke studies, which were all associated with improved neurological function. 21, 30 Thus, the observed beneficial actions of SCs are likely partly because of skewing microglia/macrophages toward a neuroprotective and neuroregenerative phenotype (Table).