Miniature stick-packaging - an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems
Miniature stick-packaging - an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems
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DOI：
10.1039/c3lc50404b
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发表时间：
2013-01-01
期刊：
影响因子：
6.1
通讯作者：
von Stetten, Felix
中科院分区：
文献类型：
--
作者：
van Oordt, Thomas;Barb, Yannick;von Stetten, Felix
用管状复合箔袋粘贴包装商品已成为食品和药品包装的流行技术。我们将用于芯片实验室系统的微型棒状包装用于预先存储和按需释放液体和干试剂，体积范围为80-500亩L。集成的易碎密封使试剂能够压力控制释放，并简化了芯片实验室系统的布局，从而使该包装成为一个功能强大的微流控释放单元。易碎密封件被调整到规定的爆破压力范围，范围从20到140 kpa。应用的超声波焊接工艺允许对温度敏感试剂进行包装。棒装包装已经成功地进行了回收试验(释放了99%(标准偏差=1%)的250亩L预储液)、长期储存试验(只有损失
Stick-packaging of goods in tubular-shaped composite-foil pouches has become a popular technology for food and drug packaging. We miniaturized stick-packaging for use in lab-on-a-chip (LOAC) systems to pre-store and on-demand release the liquid and dry reagents in a volume range of 80-500 mu l. An integrated frangible seal enables the pressure-controlled release of reagents and simplifies the layout of LOAC systems, thereby making the package a functional microfluidic release unit. The frangible seal is adjusted to defined burst pressures ranging from 20 to 140 kPa. The applied ultrasonic welding process allows the packaging of temperature sensitive reagents. Stick-packs have been successfully tested applying recovery tests (where 99% (STDV = 1%) of 250 mu l pre-stored liquid is released), long-term storage tests (where there is loss of only