Quality assessment of delineation and dose planning of early breast cancer patients included in the randomized Skagen Trial 1
Quality assessment of delineation and dose planning of early breast cancer patients included in the randomized Skagen Trial 1
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DOI：
10.1016/j.radonc.2017.03.011
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发表时间：
2017-05-01
影响因子：
5.7
通讯作者：
Offersen, Birgitte V.
中科院分区：
文献类型：
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作者：
Francolini, Giulio;Thomsen, Mette S.;Offersen, Birgitte V.
背景和目的：报告 Skagen 试验 1 的质量评估 (QA)，探索具有区域淋巴结放疗指征的乳腺癌患者的大分割。材料和方法：评估随机选择的剂量计划中关于靶体积描绘和剂量参数（Dmin、Dmax、D98%、D95% 和 D2%）的方案偏差。根据 ESTRO 指南，通过基于图集的自动分割获得目标体积描绘，并集中批准为黄金标准 (GS)。测量了骰子与原始轮廓的相似性得分（DSC）。报告了在两个轮廓中测量的剂量参数，以评估其剂量测定结果。结果：评估包括来自 4 个国家 12 个中心的 88 项计划。 DSC 在轮廓绘制方面表现出高度一致性，99% 和 96% 的患者完整描绘了目标体积和危险器官。 76% 的患者未发现剂量测定结果出现偏差，82% 和 95% 的患者成功覆盖乳房/胸壁和 CTVn_L2-4-胸间。原始描绘和 GS 的剂量测定结果具有可比性。结论：QA 显示大多数患者具有较高的方案依从性和足够的剂量覆盖范围。轮廓观察者之间的变异性较低。无论原始分割还是 GS 分割，剂量参数均与方案一致。 (C) 2017 Elsevier B.V. 保留所有权利。
Background and purpose: To report on a Quality assessment (QA) of Skagen Trial 1, exploring hypofractionation for breast cancer patients with indication for regional nodal radiotherapy.Material and methods: Deviations from protocol regarding target volume delineations and dose parameters (Dmin, Dmax, D98%, D95% and D2%) from randomly selected dose plans were assessed. Target volume delineation according to ESTRO guidelines was obtained through atlas based automated segmentation and centrally approved as gold standard (GS). Dice similarity scores (DSC) with original delineations were measured. Dose parameters measured in the two delineations were reported to assess their dosimetric outcome.Results: Assessment included 88 plans from 12 centres in 4 countries. DSC showed high agreement in contouring, 99% and 96% of the patients had a complete delineation of target volumes and organs at risk. No deviations in the dosimetric outcome were found in 76% of the patients, 82% and 95% of the patients had successful coverage of breast/chestwall and CTVn_L2-4-interpectoral. Dosimetric outcomes of original delineation and GS were comparable.Conclusions: QA showed high protocol compliance and adequate dose coverage in most patients. Inter observer variability in contouring was low. Dose parameters were in harmony with protocol regardless original or GS segmentation. (C) 2017 Elsevier B.V. All rights reserved.