Uncoupling and reactive oxygen species (ROS) - A double-edged sword for β-cell function? "Moderation in all things"
Uncoupling and reactive oxygen species (ROS) - A double-edged sword for β-cell function? "Moderation in all things"
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DOI：
10.1016/j.beem.2012.08.002
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发表时间：
2012-12-01
影响因子：
7.4
通讯作者：
Yehuda-Shnaidman, Einav
中科院分区：
文献类型：
--
作者：
Collins, Sheila;Pi, Jingbo;Yehuda-Shnaidman, Einav
线粒体能够（a）管理燃料输入以氧化产生三磷酸腺苷（ATP），同时（b）保护自身和细胞环境免受电子泄漏的影响，电子泄漏可以产生高活性氧（ROS），这是一种微妙的平衡行为。 ATP 是细胞的货币，因此作为许多激酶和离子通道的底物伙伴发挥信号传导功能。虽然各种 ROS 物种被视为危险且有毒的分子群，但它也具有来自线粒体和其他酶源的信号作用：一把双刃剑。目前了解 ROS 作为信号（通常称为过氧化氢 (H2O2)）影响的生化机制的努力令人兴奋，但 ROS 效应的这种双重性也给管理其水平以保护细胞带来了挑战。线粒体解偶联蛋白 2 (UCP2) UCP3 和通透性转换孔对于尝试了解线粒体衍生的 ROS 在细胞中的作用至关重要。在这篇文章中，我们反思线粒体！ ROS 和解偶联蛋白作为信号调节剂。看来，当谈到 ROS 并解开“凡事适度”这句谚语是贴切的。 (C) 2012 Elsevier Ltd. 保留所有权利。
The ability of the mitochondrion to (a) manage fuel import to oxidize for adenosine tri-phosphate (ATP) generation while (b) protecting itself and the cellular environment from electron leak, which can generate highly reactive oxygen species (ROS) is a delicate balancing act. ATP is the currency of the cell and as such serves a signaling function as a substrate partner to many kinases and ion channels. While various ROS species have been viewed as a dangerous and toxic group of molecules, it also has a role as a signal derived from mitochondria, as well as other enzymatic sources: a double-edged sword. Current efforts to understand the biochemical mechanisms affected by ROS as a signal - usually noted to be hydrogen peroxide (H2O2) - are exciting, but this duality of ROS effects also pose challenges in managing its levels to protect cells. The mitochondrial uncoupling protein-2 (UCP2) UCP3, and the permeability transition pore have been integral to efforts to try to understand what role mitochondrial-derived ROS have in cells. In this piece we reflect on mitochondria! ROS and uncoupling proteins as signaling regulators. It seems that when it comes to ROS and uncoupling the proverb "Moderation in all things" is apt. (C) 2012 Elsevier Ltd. All rights reserved.