Antioxidant shape amphiphiles for accelerated wound healing
Antioxidant shape amphiphiles for accelerated wound healing
复制标题
抗氧化形状两亲物可加速伤口愈合
DOI：
10.1039/d0tb00578a
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发表时间：
2020-08-21
影响因子：
7
通讯作者：
Li, Yiwen
中科院分区：
文献类型：
--
作者：
Li, Zhan;Zhang, Jianhua;Li, Yiwen
Shape amphiphiles refer to a class of molecular conjugates composed by distinct building blocks with incommensurate shapes and chemical interactions. Whilst extensive efforts have been devoted to the solid state self-assembly and nanolithography applications of shape amphiphiles, only very limited examples of their usage in the biomedical field have been explored. In this work, we reported a series of gallic acid functionalized polyhedral oligomeric silsesquioxane (POSS)-based shape amphiphiles with various macromolecular architectures for efficient and accelerated wound healing. These antioxidant giant amphiphiles demonstrated good biocompatibility and strong free radical scavenging activity to prevent cell oxidative damage and then promote wound recovery. We describe these POSS-based antioxidant shape amphiphiles in an initial proof-of-concept study and propose that this family of functional giant amphiphiles will be useful in regenerative biomedicine.
