Adiponectin levels associated with the development of hypertension: A prospective study
Adiponectin levels associated with the development of hypertension: A prospective study
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DOI：
10.1291/hypres.31.229
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发表时间：
2008-02-01
影响因子：
5.4
通讯作者：
Une, Hiroshi
中科院分区：
文献类型：
--
作者：
Imatoh, Takuya;Miyazaki, Motonobu;Une, Hiroshi
脂联素是最近发现的一种蛋白质，似乎只由脂肪细胞分泌，是最丰富的脂肪组织来源的蛋白质。虽然最近的一些研究已经证明了脂联素水平与高血压之间的联系，但这些研究都是横断面设计的，结果也不一致。因此，我们进行了一项前瞻性研究，以阐明脂联素在高血压发生中的作用。本研究结果表明，高血压患者血清脂联素水平明显低于正常血压患者。此外，在logistic回归分析中，最低四分位数的受试者的风险比最高四分位数的受试者高3.72倍。即使在调整了潜在的混杂因素后，这种关联也被发现是显著的。低血清脂联素水平被发现与高血压发展的高风险独立相关。因此，我们的研究结果表明，低脂联素血症是一种新的高血压预测指标。
Adiponectin is a recently discovered protein that seems to be exclusively secreted by adipocytes and is the most abundant adipose tissue-derived protein. While some recent studies have demonstrated an association between adiponectin levels and hypertension, these studies were cross-sectional in design, and the results have been inconsistent. Therefore we performed a prospective study to elucidate the role of adiponectin in the development of hypertension. The results of this study showed that serum adiponectin levels were significantly lower in hypertensive subjects than in normotensive subjects. Moreover, in logistic regression analysis, the subjects in the lowest quartile had a 3.72-fold higher risk than those in the highest quartile. Even after adjusting for potential confounding factors, this association was found to be significant. Low serum adiponectin levels were found to be independently associated with a higher risk for the development of hypertension. Our results therefore suggest that hypoadiponectinemia is a novel predictor of hypertension.