Multifaceted role of prohibitin in cell survival and apoptosis.
Multifaceted role of prohibitin in cell survival and apoptosis.
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抑制素在细胞存活和凋亡中的多方面作用
DOI：
10.1007/s10495-015-1143-z
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Song L
中科院分区：
文献类型：
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作者：
Peng YT;Chen P;Ouyang RY;Song L
人真核细胞抑制素（prohibitin-1和prohibitin-2）是一种具有不同细胞定位的膜蛋白。它参与多种细胞功能，包括能量代谢、增殖、凋亡和衰老。prohibitin的亚细胞定位可能决定其功能。膜抑制素调节细胞膜转运信号，核抑制素控制转录激活和细胞周期，线粒体抑制素复合物稳定线粒体基因组并调节线粒体动力学、线粒体形态、线粒体生物合成和线粒体内源性凋亡途径。此外，在凋亡信号的作用下，抑制素还可转位到细胞核或线粒体内，其亚细胞穿梭是凋亡过程所必需的。细胞凋亡是细胞程序性死亡的过程，对维持正常的生理功能非常重要。因此，抑制素含量、转录后修饰（即磷酸化）或核或线粒体易位的任何改变都可能影响细胞命运。了解prohibitin的表达和调控机制可能对未来的研究有帮助。本文综述了抑制素在细胞存活和凋亡调控中的多方面和重要作用。
Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.