Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans.
Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans.
复制标题
DOI：
10.1007/s11892-005-0041-0
复制
发表时间：
2005-04-01
影响因子：
4.2
通讯作者：
Kadowaki, Takashi
中科院分区：
文献类型：
--
作者：
Hara, Kazuo;Yamauchi, Toshimasa;Kadowaki, Takashi
脂联素是一种胰岛素增敏和抗动脉粥样硬化的激素，在动物模型中补充脂联素可改善胰岛素抵抗和动脉粥样硬化。在人类中，最近的研究表明，脂联素水平是发展2型糖尿病和冠状动脉疾病的良好预测因子。脂联素水平的降低是由遗传因素（如脂联素基因的单核苷酸多态性）和环境因素（如高脂饮食）之间的相互作用引起的。增加脂联素血水平或增强脂联素作用的药物可能是改善胰岛素抵抗和2型糖尿病的理想药物。
Adipocyte-derived adiponectin is an insulin-sensitizing and antiatherosclerotic hormone, and replenishment of adiponectin in animal models ameliorated insulin resistance and atherosclerosis. In humans, recent studies have demonstrated that adiponectin level is a good predictor of developing type 2 diabetes and coronary artery disease. Decreasing level of adiponectin is caused by the interaction between genetic factors, such as single nucleotide polymorphisms in the adiponectin gene, and environmental factors, such as high-fat diet. Agents that increase blood level of adiponectin or enhance the actions of adiponectin can be an ideal medicine for ameliorating insulin resistance and type 2 diabetes.