Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy
Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy
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基于金簇的多功能近红外发射纳米缀合物用于肿瘤成像和治疗
DOI：
10.1016/j.biomaterials.2012.08.034
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发表时间：
2012-11-01
期刊：
影响因子：
14
通讯作者：
Gu, Yueqing
中科院分区：
文献类型：
--
作者：
Chen, Haiyan;Li, Bowen;Gu, Yueqing
金纳米团簇（NC）功能化作为荧光探针和前药用于肿瘤诊断和治疗。首先，将Au纳米粒子与蛋氨酸（Met）和MPA（一种近红外（NIR）荧光染料）偶联，得到Au-Met-MPA探针。在体外和体内证实了Met赋予的肿瘤靶向能力以及这种造影剂的低细胞毒性及其用于肿瘤靶向成像的临床潜力。其次。以蛋氨酸修饰的Au纳米粒为载体，将临床上广泛应用的抗癌药物阿霉素（DOX）固定在纳米粒上，制备了前药Au-Met-DOX。证明了该前药的增强的肿瘤亲和力和改善的抗肿瘤活性。本研究的结果不仅表明了功能配体修饰的无毒Au NCs用于肿瘤靶向成像的前景，而且证实了Au NCs作为前药设计的核心在肿瘤治疗领域的广阔前景。(C)2012爱思唯尔有限公司保留所有权利。
Gold nanoclusters (NCs) were functionalized as a fluorescent probe and a pro-drug intended for tumor diagnosis and therapy. Firstly, Au NCs were conjugated with methionine (Met) and MPA, a near-infrared (NIR) fluorescent dye, giving a probe, Au-Met-MPA. The tumor targeting capability endowed by Met as well as low cytotoxicity of this contrast agent and its clinical potential for tumor targeting imaging were demonstrated in vitro and in vivo. Secondly. Doxorubicin (DOX), a widely used clinical anti-cancer drug, was immobilized on the methionine modified Au NCs to form a pro-drug, Au-Met-DOX. The enhanced tumor affinity and improved anti-tumor activity of this pro-drug were demonstrated. Results in this study suggest not only the prospect of non-toxic Au NCs modified with functional ligands for tumor-targeted imaging, but also confirm the promising future of Au NCs as a core for the design of prodrug in the field of cancer therapy. (C) 2012 Elsevier Ltd. All rights reserved.