Beer, wine consumption, and 10-year CVD incidence: the ATTICA study
Beer, wine consumption, and 10-year CVD incidence: the ATTICA study
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DOI：
10.1038/s41430-018-0296-6
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发表时间：
2019-07-01
影响因子：
4.7
通讯作者：
Pitsavos, Christos
中科院分区：
文献类型：
--
作者：
Panagiotakos, Demosthenes B.;Kouli, Georgia-Maria;Pitsavos, Christos
背景/目的低/中度饮酒似乎对心血管疾病（CVD）有保护作用。本研究旨在调查葡萄酒/啤酒消费量与10年心血管疾病发病率的关系。在2001-2002年期间，3042名无cvd的成年人同意参加ATTICA研究；其中2583人完成了10年的随访（85%的参与率），但在2020名参与者（总保留率66%）中可获得关于致死性/非致死性心血管疾病发病率（心肌梗死、心绞痛、心脏缺血、心力衰竭、慢性心律失常和中风）的准确信息。评估了酒精/乙醇摄入量和消费的酒精饮料；参与者被分为三组（不使用；每周1杯）。未发生心血管疾病事件的参与者中有56%报告饮酒，发生心血管疾病事件的参与者中有49%报告饮酒（p = 0.04）；而无心血管事件的受试者乙醇摄入量为14 +/- 16 g，有心血管事件的受试者乙醇摄入量为21 +/- 18 g （p < 0.001）。观察到低葡萄酒/啤酒摄入量（= 1杯/周）与发生心血管疾病的风险之间存在强烈的负相关和类似的关联[HR: 0.40, 95%可信区间（CI）： 0.17-0.98；（HR: 0.43, 95% CI: 0.20-0.93），与不服用相比。与不饮酒者相比，每周饮酒量超过1杯的参与者没有发现显著关联。与20 g/天相比，cvd风险hr （95% CI）分别为0.60（0.40-0.98）、1.22（0.60-1.14）和1.81（0.70-4.61）。结论本研究揭示了低葡萄酒/啤酒消费量对心血管疾病发病率的相似结果，主要是由于其对低度慢性炎症的影响。
Background/objectives Low/moderate alcohol consumption seems to be protective against cardiovascular disease (CVD). This study aimed to investigate the association of wine/beer consumption with the 10-year CVD incidence.Subjects/methods During 2001-2002, 3042 CVD-free adults consented to participate in the ATTICA study; of them 2583 completed the 10-year follow-up (85% participation rate), but precise information about fatal/nonfatal CVD incidence (myocardial infarction, angina pectoris, cardiac ischemia, heart failure, chronic arrhythmias, and stroke) was available in 2020 participants (overall retention rate 66%). Alcohol/ethanol intake and the alcoholic beverages consumed were assessed; participants were categorized into three groups (no use; 1 glass/week).Results Alcohol drinking was reported by 56% of the participants who did not develop a CVD event and 49% of those who had (p = 0.04); whereas ethanol intake was 14 +/- 16 g among those who did not had an event vs. 21 +/- 18 g among those who had a CVD event (p < 0.001). A strong inverse and similar association between low wine/beer intake (= 1 glass/week) and the risk of developing CVD was observed [HR: 0.40, 95% confidence interval (CI): 0.17-0.98; and HR: 0.43, 95% CI: 0.20-0.93, respectively], as compared to abstention. No significant association was found in participants exceeding drinking 1 glass/week compared with abstainers. Compared to 20 g/day had CVD-risk HRs (95% CI) of 0.60 (0.40-0.98), 1.22 (0.60-1.14), and 1.81 (0.70-4.61), respectively.Conclusions This study revealed similar results of low wine/beer consumption against CVD incidence, mainly due to its implication on low-grade chronic inflammation.