Short-wavelength enrichment of polychromatic light enhances human melatonin suppression potency
Short-wavelength enrichment of polychromatic light enhances human melatonin suppression potency
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DOI：
10.1111/jpi.12221
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发表时间：
2015-04-01
影响因子：
10.3
通讯作者：
Rollag, Mark
中科院分区：
文献类型：
--
作者：
Brainard, George C.;Hanifin, John P.;Rollag, Mark
这项研究的基本目标是确定光波长的最佳组合，作为太空探索期间昼夜节律和睡眠中断的照明对策，以及生活在地球上的个人。采用单色光和选定的单色波长比较的行动光谱表明，在光谱的蓝色出现部分的短波长可见光是最有效的神经内分泌，昼夜节律和神经行为调节。这里提出的研究测试了这样一个假设，即在可见光谱的短波长部分富集的宽光谱多色荧光对健康男性和女性的松果体褪黑激素抑制更有效。共有24名受试者在三个独立的实验中接受测试。每个实验都采用了受试者内研究设计，测试了8名志愿者，以建立角膜光辐照度和夜间血浆褪黑激素抑制之间的全范围通量-响应关系。每个实验测试三种类型的荧光灯中的一种，这三种类型的荧光灯在400和500 nm之间的可见光谱的短波长端的相对发光量不同。根据国家和国际眼睛安全标准进行的危害分析确定，本研究中使用的所有光暴露都是安全的。每一个能量密度-反应曲线表明，增加角膜辐照度的光诱发逐渐增加的抑制夜间褪黑激素。这些通量响应曲线的比较支持的假设，多色荧光是更有力的褪黑激素调节时，丰富的短波长光谱。
The basic goal of this research is to determine the best combination of light wavelengths for use as a lighting countermeasure for circadian and sleep disruption during space exploration, as well as for individuals living on Earth. Action spectra employing monochromatic light and selected monochromatic wavelength comparisons have shown that short-wavelength visible light in the blue-appearing portion of the spectrum is most potent for neuroendocrine, circadian, and neurobehavioral regulation. The studies presented here tested the hypothesis that broad spectrum, polychromatic fluorescent light enriched in the short-wavelength portion of the visible spectrum is more potent for pineal melatonin suppression in healthy men and women. A total of 24 subjects were tested across three separate experiments. Each experiment used a within-subjects study design that tested eight volunteers to establish the full-range fluence-response relationship between corneal light irradiance and nocturnal plasma melatonin suppression. Each experiment tested one of the three types of fluorescent lamps that differed in their relative emission of light in the short-wavelength end of the visible spectrum between 400 and 500nm. A hazard analysis, based on national and international eye safety criteria, determined that all light exposures used in this study were safe. Each fluence-response curve demonstrated that increasing corneal irradiances of light evoked progressively increasing suppression of nocturnal melatonin. Comparison of these fluence-response curves supports the hypothesis that polychromatic fluorescent light is more potent for melatonin regulation when enriched in the short-wavelength spectrum.