Perspectives on long-acting injectable HIV antiretroviral therapy at an alternative care site: a qualitative study of people with HIV experiencing substance use and/or housing instability.
Perspectives on long-acting injectable HIV antiretroviral therapy at an alternative care site: a qualitative study of people with HIV experiencing substance use and/or housing instability.
复制标题
DOI：
10.1186/s12954-023-00730-z
复制
发表时间：
2023-01-10
影响因子：
4.4
通讯作者：
Drainoni, Mari-Lynn
中科院分区：
文献类型：
--
作者：
Fletcher, Laura;Burrowes, Shana A. B.;Khan, Ghulam Karim;Sabin, Lora;Johnson, Samantha;Kimmel, Simeon D. D.;Ruiz-Mercado, Glorimar;Pierre, Cassandra;Drainoni, Mari-Lynn
坚持每日口服抗逆转录病毒治疗（ART）和定期门诊预约对于经历健康不良社会决定因素的个人来说可能具有挑战性。在传统的诊所环境之外进行长效注射ART可能是解决依从性障碍的一个有希望的解决方案，但需要进行更多的研究来评估患者的观点。本研究评估了难以坚持传统艾滋病毒护理模式的艾滋病毒感染者（PLWH）的观点，并评估了在传统艾滋病毒诊所之外接受长效ART注射以解决艾滋病毒护理障碍的可行性和可接受性。定性访谈（n = 26）进行了PLWH谁经历了坚持的障碍。参与者被转介到该研究的工作人员从项目信托，减少伤害和性传播感染/艾滋病毒诊所下降。访谈于二零二一年五月至十一月期间进行。访谈记录，专业转录，编码和定性分析，使用综合促进行动的研究实施卫生服务框架。我们确定了6个主要主题，关于接受长效注射治疗艾滋病毒的可接受性，以及在替代护理场所接受注射的可接受性和可行性。与会者指出，他们：（1）对他们的HIV护理和ART依从性的重要性有一般的了解，（2）更喜欢长效注射而不是每日药丸方案，（3）对注射安全性和有效性表示担忧，（4）对长效注射的递送有特定的后勤方面，包括注射给药的位置，他们认为这将提高他们的依从性，（5）有信心他们可以变得不可检测，然后完成开始接受注射所需的口服导入，以及（6）看到潜在的障碍，这些障碍仍然是成功坚持长效注射的问题。为了更好地治疗那些生活在具有挑战性的社会健康决定因素中的人的艾滋病毒，包括在非传统护理环境中进行长效注射在内的干预措施可能被证明是一种有希望的治疗选择。
Adherence to daily oral antiretroviral therapy (ART) and regular clinic appointments can be challenging for individuals who experience adverse social determinants of health. Long-acting injectable ART administered outside of traditional clinic settings may be a promising solution to adherence barriers, but additional research is needed to assess patients’ perspectives. This study assessed perspectives of people living with HIV (PLWH) who had difficulty with adherence to traditional HIV care models and evaluated feasibility and acceptability of receiving a long-acting ART injection at a location outside of a traditional HIV clinic to address barriers to HIV care. Qualitative interviews (n = 26) were conducted with PLWH who had experienced barriers to adherence. Participants were referred to the study by staff from Project Trust, a drop in harm reduction and sexually transmitted infection/HIV clinic. The interviews were conducted between May and November 2021. Interviews were recorded, professionally transcribed, coded, and analyzed qualitatively using the integrated-Promoting Action on Research Implementation in Health Services framework. We identified 6 main themes regarding the acceptability of receiving a long-acting injection to treat HIV, and the acceptability and feasibility of receiving injections at an alternative care site. Participants specified that they: (1) have a general understanding about their HIV care and the importance of ART adherence, (2) prefer a long-acting injection over a daily pill regimen, (3) expressed concerns about injection safety and efficacy, (4) had specific logistical aspects around the delivery of long-acting injections, including location of injection administration, that they believed would improve their ability to adhere, (5) have confidence that they can become undetectable and then complete the oral lead-in required to begin receiving the injection, and (6) see potential barriers that remain a concern for successful adherence to long-acting injections. To better treat HIV among people who are living with challenging social determinants of health, interventions that include a long-acting injection in a non-traditional care setting may prove to be a promising treatment option.
登录
查看更多内容
DOI：
10.1097/qad.0000000000002883
发表时间：
2021-07-15
期刊：
AIDS (London, England)
影响因子：
--
作者：
Cutrell AG;Schapiro JM;Perno CF;Kuritzkes DR;Quercia R;Patel P;Polli JW;Dorey D;Wang Y;Wu S;Van Eygen V;Crauwels H;Ford SL;Baker M;Talarico CL;Clair MS;Jeffrey J;White CT;Vanveggel S;Vandermeulen K;Margolis DA;Aboud M;Spreen WR;van Lunzen J
通讯作者：
van Lunzen J
影响因子：
3.1
作者：
Socias ME;Milloy MJ
通讯作者：
Milloy MJ
影响因子：
6.4
作者：
Winetsky, Daniel;Burack, Daniel;Scherer, Matthew
通讯作者：
Scherer, Matthew
影响因子：
2.8
作者：
Mantsios A;Murray M;Karver TS;Davis W;Galai N;Kumar P;Swindells S;Bredeek UF;García RR;Antela A;Gomis SC;Bernáldez MP;Czarnogorski M;Hudson K;Walters N;Kerrigan D
通讯作者：
Kerrigan D
影响因子：
7.2
作者：
Harvey, Gill;Kitson, Alison
通讯作者：
Kitson, Alison