Role of mTOR in physiology and pathology of the nervous system
Role of mTOR in physiology and pathology of the nervous system
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DOI：
10.1016/j.bbapap.2007.08.015
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Jaworski, Jacek
中科院分区：
文献类型：
--
作者：
Swiech, Lukasz;Perycz, Malgorzata;Jaworski, Jacek
哺乳动物雷帕霉素靶蛋白（mTOR）是一种丝氨酸-苏氨酸蛋白激酶，其响应于细胞外信号、营养可用性、细胞的能量状态和应激而调节几种细胞内过程。mTOR调节神经元的存活、分化和发育。轴突生长和导航、树突状分支以及突触发生依赖于适当的mTOR活性。在成人大脑中，mTOR对突触可塑性、学习和记忆形成以及大脑控制食物摄取至关重要。最近的研究表明，mTOR活性在神经系统的各种病理状态中被改变，包括脑肿瘤、结节性硬化症、皮质增生症和神经退行性疾病如阿尔茨海默病、帕金森病和亨廷顿病。本文综述了mTOR在神经系统生理学和病理学中的作用，特别关注mTOR下游可能有助于神经元发育，可塑性和神经病理学的分子靶点。(C)2007 Elsevier B. V.保留所有权利。
Mammalian target of rapamycin (mTOR) is a serine-threonine protein kinase that regulates several intracellular processes in response to extracellular signals, nutrient availability, energy status of the cell and stress. mTOR regulates survival, differentiation and development of neurons. Axon growth and navigation, dendritic arborization, as well as synaptogenesis, depend on proper mTOR activity. In adult brain mTOR is crucial for synaptic plasticity, learning and memory formation, and brain control of food uptake. Recent studies reveal that mTOR activity is modified in various pathologic states of the nervous system, including brain tumors, tuberous sclerosis, cortical displasia and neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. This review presents current knowledge about the role of mTOR in the physiology and pathology of the nervous system, with special focus on molecular targets acting downstream of mTOR that potentially contribute to neuronal development, plasticity and neuropathology. (C) 2007 Elsevier B.V. All rights reserved.