KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
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DOI：
10.1172/jci40567
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发表时间：
2010-04-01
影响因子：
15.9
通讯作者：
Ganem, Don
中科院分区：
文献类型：
--
作者：
Ganem, Don
卡波西肉瘤 (KS) 与新型人类疱疹病毒（卡波西肉瘤相关疱疹病毒 [KSHV]）感染的联系是当代生物医学研究的巨大成功之一，是通过对流行病学和临床研究的细致了解，利用先进的基因组技术实现的。临床研究的深入见解对了解 KSHV 感染诱发 KS 的分子机制的持续努力继续产生重大影响。本文综述了 KS 发病机制的最新进展，特别强调临床、病理和分子观察，强调了这一过程与其他致癌病毒的肿瘤发生之间的许多差异。
The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi sarcoma-associated herpesvirus [KSHV]) is one of the great successes of contemporary biomedical research and was achieved by using advanced genomic technologies in a manner informed by a nuanced understanding of epidemiology and clinical investigation. Ongoing efforts to understand the molecular mechanisms by which KSHV infection predisposes to KS continue to be powerfully influenced by insights emanating from the clinic. Here, recent developments in KS pathogenesis are reviewed, with particular emphasis on clinical, pathologic, and molecular observations that highlight the many differences between this process and tumorigenesis by other oncogenic viruses.