Review: toxicometabolomics.
Review: toxicometabolomics.
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DOI：
10.1002/jat.2874
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发表时间：
2013-12
影响因子：
3.3
通讯作者：
Zhao, Liang
中科院分区：
文献类型：
--
作者：
Bouhifd, Mounir;Hartung, Thomas;Hogberg, Helena T.;Kleensang, Andre;Zhao, Liang
关键词：
代谢组学在毒理学中的应用正在迅速增加，特别是由于质谱学的进步，质谱学在生命科学中广泛用于疾病状态的表型分析。毒理学的优势在于，可以通过监测时间和剂量来实验诱导代谢组学变化。本文综述了所采用的不同技术，并举例说明了它们在毒理学各个领域的应用。代谢组学的一个突出用途是识别毒性特征-预测危害表现的代谢物变化模式。越来越多地发现表明某种危害表现的这种特征，表明某些作用模式导致新陈代谢的特定紊乱。这可能有助于推断潜在的毒性途径，这些途径整体上形成了人类毒素组，这是实现21世纪毒性测试愿景的关键概念。本文综述了代谢组学的技术和原理及其在毒理学中的应用，并对代谢组学的生物信息学、途径鉴定和质量保证等方面进行了全面的综述。此外，这篇评论还提出了在监管背景下进一步代谢组学应用的前景。
Metabolomics use in toxicology is rapidly increasing, particularly owing to advances in mass spectroscopy, which is widely used in the life sciences for phenotyping disease states. Toxicology has the advantage of having the disease agent, the toxicant, available for experimental induction of metabolomics changes monitored over time and dose. This review summarizes the different technologies employed and gives examples of their use in various areas of toxicology. A prominent use of metabolomics is the identification of signatures of toxicity – patterns of metabolite changes predictive of a hazard manifestation. Increasingly, such signatures indicative of a certain hazard manifestation are identified, suggesting that certain modes of action result in specific derangements of the metabolism. This might enable the deduction of underlying pathways of toxicity, which, in their entirety, form the Human Toxome, a key concept for implementing the vision of Toxicity Testing for the 21st century. This review summarizes the current state of metabolomics technologies and principles, their uses in toxicology and gives a thorough overview on metabolomics bioinformatics, pathway identification and quality assurance. In addition, this review lays out the prospects for further metabolomics application also in a regulatory context.
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影响因子：
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通讯作者：
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作者：
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通讯作者：
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