Bioinspired 3D Multilayered Shape Memory Scaffold with a Hierarchically Changeable Micropatterned Surface for Efficient Vascularization
Bioinspired 3D Multilayered Shape Memory Scaffold with a Hierarchically Changeable Micropatterned Surface for Efficient Vascularization
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DOI：
10.1021/acsami.7b05933
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发表时间：
2017-06-14
影响因子：
9.5
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
--
作者：
Liu, Dian;Xiang, Tao;Zhou, Shaobing
How to achieve three-dimensional (3D) cell alignment and subsequent prompt tissue regeneration remains a great challenge. Here, inspired by the interior 3D architecture of native, arteries, we develop a new 3D multilayered shape memory vascular scaffold with a hierarchically changeable micropatterned surface for vascularization. The shape memory function renders the implantation of the scaffold safe and convenient via minimally invasive surgery. By co-culturing endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) on the 3D-multilayered structure, the inner monolayer, which has a square micropatterned-surface, can promote EC adhesion and migration, resulting-in a rapid endothelialization, and the outer multilayers, which have rectangular micropatterned surfaces, can induce a circumferential alignment of VSMCs. After implantation in the cervical artery of a New Zealand rabbit for 120 days, the graft developed a high capacity for modulating cellular 3D alignment, to generate a neonatal functional blood Vessel:with-an endothelium layer in the inner layer and multilevel VSMC,circumferential. alignments in the outer layers.
