Ethanol Detection at the Parts per Billion Level with Single‐Stranded‐DNA‐Modified Graphene Field‐Effect Transistors
Ethanol Detection at the Parts per Billion Level with Single‐Stranded‐DNA‐Modified Graphene Field‐Effect Transistors
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DOI：
10.1002/pssb.201900376
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发表时间：
2019-09
期刊：
影响因子：
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通讯作者：
Ryo Nozaki;T. Ikuta;Kinuko Ueno;K. Tsukakoshi;K. Ikebukuro;K. Maehashi
中科院分区：
文献类型：
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作者：
Ryo Nozaki;T. Ikuta;Kinuko Ueno;K. Tsukakoshi;K. Ikebukuro;K. Maehashi
为了实现疾病的早期诊断，需要使用紧凑的设备以十亿分之一（ppb）检测呼出气体中的气体。在此，制造单链DNA修饰的石墨烯场效应晶体管（FET）并测量传输特性。结果表明，通过引入ppb级的乙醇气体获得了传输特性的变化，表明单链DNA修饰的石墨烯FET检测到ppb级的气体。此外，通过修饰DNA序列1或序列2，分别观察到转移特性的正电压偏移和负电压偏移。相反，使用DNA序列3几乎不能获得位移，其具有用于吸附分子的刚性构象。这些不同的传输特性的行为归因于DNA构象的变化时，气体被吸附。因此，单链DNA修饰的石墨烯FET具有相当大的潜力，可以根据DNA序列的设计在低浓度下检测各种气体，使其在疾病诊断中具有广阔的应用前景。
For realizing the early diagnosis of diseases, detection of gases in exhaled breath in parts per billion (ppb) using compact devices is necessary. Herein, single‐stranded‐DNA‐modified graphene field‐effect transistors (FETs) are fabricated and the transfer characteristics are measured. The results reveal that shifts in the transfer characteristics are obtained by introducing ethanol gas at the ppb level, indicating that single‐stranded‐DNA‐modified graphene FETs detect the gas at the ppb level. Moreover, by modifying DNA sequence 1 or sequence 2, the positive and negative voltage shifts of transfer characteristics are observed, respectively. In contrast, the shifts are hardly obtained using DNA sequence 3, which has a rigid conformation for adsorption of molecules. These differences in the behaviors of the transfer characteristics are attributed to the change in DNA conformation when gas is adsorbed. Therefore, single‐stranded‐DNA‐modified graphene FETs have considerable potential to detect various gases at a low concentration depending on the design of DNA sequences, enabling their promising applications in disease diagnosis.