Gold-Catalyzed Multiple Cascade Reaction of 2-Alkynylphenylazides with Propargyl Alcohols
Gold-Catalyzed Multiple Cascade Reaction of 2-Alkynylphenylazides with Propargyl Alcohols
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金催化 2-炔基苯基叠氮化物与炔丙醇的多重级联反应
DOI：
10.1002/chem.201406456
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发表时间：
2015-02-23
影响因子：
4.3
通讯作者：
Zhang, Liming
中科院分区：
文献类型：
--
作者：
Li, Nan;Wang, Tian-Yi;Zhang, Liming
在金的催化下，2-炔基芳氮化物和炔醇之间发生了一种前所未有的多级联反应，使得一步经济的合成具有广泛结构多样性的吡咯烷酮衍生物成为可能。在这个反应中，金的络合物以串联的方式参与三重催化。此外，光学纯的烯醇底物的高效手性转移使手性吡咯烷酮衍生物能够方便地获得具有两个立体中心的手性吡咯烷酮衍生物，其中包括一个四元中心，具有良好的光学纯度水平。
An unprecedented gold-catalyzed multiple cascade reaction between 2-alkynyl arylazides and alkynols has been developed, allowing for the step-economical synthesis of pyrroloindolone derivatives with a wide range of structural diversity. In this reaction, the gold complex participates in triple catalysis in tandem fashion. Moreover, the efficient chirality transfer from optically pure alkynol substrates enables facile access to chiral pyrroloindolone derivatives with two stereogenic centers, including a quaternary one, with excellent levels of optical purity.