Association between prepregnancy body mass index and congenital heart defects
Association between prepregnancy body mass index and congenital heart defects
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DOI：
10.1016/j.ajog.2009.08.005
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发表时间：
2010-01-01
影响因子：
9.8
通讯作者：
Riehle-Colarusso, Tiffany J.
中科院分区：
文献类型：
--
作者：
Gilboa, Suzanne M.;Correa, Adolfo;Riehle-Colarusso, Tiffany J.
目的：探讨孕前体重指数(BMI)与先天性心脏病(CHDS)的关系。研究设计：纳入1997-2004年全国出生缺陷预防研究登记的先天性心脏病病例(n=6440)和非出生缺陷儿(n=5673)。结果：合并先天性心脏病的调整优势比为1.16(95%可信区间，1.05-1.29)，1.15(95%可信区间，1.00-1.32)，1.31(95%可信区间，1.00-1.32)，1.11-1.56)分别为超重、中度肥胖和重度肥胖。与BMI升高相关的表型有：圆锥干畸形(法洛四联症)、完全性肺静脉返流异常、左心发育不良综合征、右室流出道(RVOT)缺陷(肺动脉瓣狭窄)和间隔缺陷(继发孔型房间隔缺损)。结论：这些结果证实了前人的研究结果，并提示肥胖与圆锥干畸形和RVOT缺陷之间存在新的联系。
OBJECTIVE: The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs).STUDY DESIGN: These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004).RESULTS: Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05-1.29), 1.15 (95% CI, 1.00-1.32), and 1.31 (95% CI, 1.11-1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (>= 25.0 kg/m(2)) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect).CONCLUSION: These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.