Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning.
Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning.
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DOI：
10.1523/jneurosci.0363-11.2011
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发表时间：
2011-05-18
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影响因子：
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通讯作者：
Jentsch JD
中科院分区：
文献类型：
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作者：
Groman SM;Lee B;London ED;Mandelkern MA;James AS;Feiler K;Rivera R;Dahlbom M;Sossi V;Vandervoort E;Jentsch JD
奖励敏感性和行为灵活性的偏差，特别是在改变或停止行为以应对不断变化的环境突发事件的能力，是几种神经精神疾病的重要表型维度。神经影像学证据表明，通过多巴胺D2样受体的多巴胺信号的变化可能会影响这些表型，以及相关的精神疾病，但这种影响是通过具体的神经认知机制是未知的。为了解决这个问题，我们研究了黑长尾猴在辨别学习过程中对强化的行为敏感性与D2样受体可用性之间的关系。研究人员评估了猴子获得、保留和逆转三项选择、视觉辨别问题的能力，一旦行为表现稳定下来，他们就接受了正电子发射断层扫描（PET）。D2-样受体在背侧纹状体的可用性是不相关的个体差异的能力，获得或保留视觉的歧视，但涉及到的试验数量需要达到标准的逆转阶段的任务。D2样受体的可用性也与学习过程中对积极反馈的行为敏感性密切相关，但与消极反馈无关。这些结果超越了电生理学的发现，通过证明参与纹状体多巴胺能标记物的反馈敏感性和行为灵活性的个体差异，提供了深入了解神经精神障碍，这些缺陷的功能受到影响的神经机制。
Deviations in reward sensitivity and behavioral flexibility, particularly in the ability to change or stop behaviors in response to changing environmental contingencies, are important phenotypic dimensions of several neuropsychiatric disorders. Neuroimaging evidence suggests that variation in dopamine signaling through dopamine D2-like receptors may influence these phenotypes, as well as associated psychiatric conditions, but the specific neurocognitive mechanisms through which this influence is exerted are unknown. To address this question, we examined the relationship between behavioral sensitivity to reinforcement during discrimination learning and D2-like receptor availability in vervet monkeys. Monkeys were assessed for their ability to acquire, retain and reverse three-choice, visual-discrimination problems, and once behavioral performance had stabilized, they received positron emission tomography (PET) scans. D2-like receptor availability in dorsal aspects of the striatum was not related to individual differences in the ability to acquire or retain visual discriminations but did relate to the number of trials required to reach criterion in the reversal phase of the task. D2-like receptor availability was also strongly correlated with behavioral sensitivity to positive, but not negative, feedback during learning. These results go beyond electrophysiological findings by demonstrating the involvement of a striatal dopaminergic marker in individual differences in feedback sensitivity and behavioral flexibility, providing insight into the neural mechanisms that are affected in neuropsychiatric disorders that feature these deficits.