Activation of follicle development: The primordial follicle
Activation of follicle development: The primordial follicle
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DOI：
10.1016/s0093-691x(01)00478-2
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发表时间：
2001-04-01
期刊：
影响因子：
2.8
通讯作者：
Picton, HM
中科院分区：
文献类型：
--
作者：
Picton, HM
原始卵泡的形成和生长的研究是我们理解雌性配子产生的基础。在所有哺乳动物雌性中，完整的卵母细胞在胎儿发育期间建立。这种原始卵泡的储存是不可再生的，并为成年人的整个生殖寿命服务。因此，胎儿卵巢发育的正确程序和形成的原始卵泡的数量将限制卵巢的生殖力。原始卵泡的特征是单个卵母细胞被不同数量的前颗粒细胞包围。相对较小的体积，未分化的状态和大量的原始卵泡使它们成为动物生产，基因转移和克隆的基础和应用研究的主要候选人。此外，使用原始卵泡作为卵母细胞体外生长和成熟的来源的细胞培养系统的发展将使我们能够最大限度地提高高遗传价值女性的潜力，并缩短世代间隔。尽管存在这些可能性，但原始卵泡是卵泡发育所有阶段中了解最少的。负责维持原始卵泡池或相反激活原始卵泡生长的因子仍然难以捉摸。(C)2001年，Elsevier Science Inc.
Investigations of primordial follicle formation and growth are fundamental to our understanding of female gamete production. In all mammalian females the full complement of oocytes is established during fetal development. This store of primordial follicles is not renewable and serves the entire reproductive life span of the adult. The correct programming of fetal ovarian development and the number of primordial follicles formed will therefore limit the fecundity of the ovary. Primordial follicles are characterized by the presence of a single oocyte surrounded by a varying number of pregranulosa cells. The relatively small size, undifferentiated status and large numbers of primordial follicles make them prime candidates for use in basic and applied research in animal production, gene transfer and cloning. Furthermore, the development of cell culture systems that use primordial follicles as a source of oocytes for in vitro growth and maturation will enable us to maximize the potential of high genetic merit females and to shorten generation intervals. Despite these possibilities, primordial follicles are the least understood of all stages of follicle development. The factor(s) responsible for maintaining the primordial pool or, conversely, for activating primordial follicle growth remain elusive. (C) 2001 by Elsevier Science Inc.