Augmentation of serotonin enhances pleasant and suppresses unpleasant cortical electrophysiological responses to visual emotional stimuli in humans
Augmentation of serotonin enhances pleasant and suppresses unpleasant cortical electrophysiological responses to visual emotional stimuli in humans
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DOI：
10.1016/j.neuroimage.2004.03.022
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发表时间：
2004-07-01
期刊：
影响因子：
5.7
通讯作者：
Nathan, PJ
中科院分区：
文献类型：
--
作者：
Kemp, AH;Gray, MA;Nathan, PJ
血清素能系统是药物治疗包括抑郁症在内的多种情绪障碍的主要系统之一。然而，人们对血清素 (5-HT) 对情感现象（包括情绪行为、情绪和情绪处理）影响的神经生理学机制知之甚少。本研究的目的是调查 5-HT 如何敏锐地调节与观看不同价值的情感图像相关的稳态视觉诱发电位 (SSVEP)、心率 (HR) 和言语评分。在随机双盲安慰剂对照设计中，17 名健康受试者在两种急性治疗条件下进行了测试：安慰剂和西酞普兰（20 毫克）（一种选择性血清素再摄取抑制剂，或 SSRI）。参与者在治疗后 2 小时接受测试，同时观看 75 张图像（分为愉快、中性或不愉快）。结果表明，在安慰剂治疗下，处理不愉快的效价[不愉快的(-)中性图像]与额叶和枕叶皮层的SSVEP振幅和潜伏期的降低相关，而处理愉快的效价[愉快的(-)中性图像]与额叶和左颞顶叶皮层的振幅降低和潜伏期增加相关。振幅和潜伏期的减少都被解释为皮质激活或兴奋的替代测量。与安慰剂相比，西酞普兰将额叶和枕叶皮质内的电生理激活减弱为令人不愉快的价，但将顶枕皮质内的电生理激活（仅幅度）增强为令人愉快的价。与安慰剂相比，西酞普兰还抑制了与观看愉快和不愉快图像相关的心率差异，但没有改变受试者对情感图像的主观反应。结果表明，神经化学调节后对愉快和不愉快刺激的反应可能因不同的反应系统（即自我报告、HR 和 SSVEP）而异。电生理学研究结果表明，西酞普兰急性血清素能增强可调节情绪价刺激的皮层处理，从而增强对愉快价的反应，并抑制对不愉快价的反应。研究结果表明，抗抑郁药物对情绪的作用可能存在神经生理学机制。 (C) 2004 Elsevier Inc. 保留所有权利。
The serotonergic system is one of the major systems targeted in the pharmacological treatment of a wide range of mood disorders including depression; however, little is known about the neurophysiological mechanisms underlying the effects of serotonin (5-HT) on affective phenomena including emotional behaviours, mood and emotional processing. The aim of the current study was to investigate how 5-HT acutely modulates steady-state visually evoked potentials (SSVEP), heart rate (HR) and verbal ratings associated with the viewing of differently valent emotional images. In a randomised double-blind, placebo-con trolled design, 17 healthy subjects were tested under two acute treatment conditions: placebo and citalopram (20 mg) (a selective serotonin re-uptake inhibitor, or SSRI). Participants were tested 2 h post treatment whilst viewing 75 images (categorised as pleasant, neutral or unpleasant). Results indicate that under placebo treatment, processing of unpleasant valence [unpleasant (-) neutral images] was associated with decreases in SSVEP amplitude and latency in frontal and occipital cortices, whereas processing of pleasant valence [pleasant (-) neutral images] was associated with amplitude decreases and latency increases within frontal and left temporoparietal cortices. Decreases in both amplitude and latency are both interpreted as surrogate measures of cortical activation or excitation. Citalopram relative to placebo attenuated the electrophysiological activation to unpleasant valence within frontal and occipital cortices, but potentiated electrophysiological activation (amplitude only) to pleasant valence within parietooccipital cortices. Citalopram relative to placebo also suppressed differences in heart rate associated with the viewing of pleasant and unpleasant images, but did not alter subject's subjective responses to emotional images. Results suggest that responsiveness to pleasant and unpleasant stimuli following neurochemical modulation may vary across different response systems (i.e. self-report, HR and SSVEP). Electrophysiological findings suggest that acute serotonergic augmentation with citalopram modulates cortical processing of emotionally valent stimuli such that response to pleasant valence is potentiated and response to unpleasant valence is suppressed. The findings suggest a possible neurophysiological mechanism underlying antidepressant drug action on emotion. (C) 2004 Elsevier Inc. All rights reserved.