INTERLEUKIN-1 STIMULATES ALDOSTERONE SECRETION - INVOLVEMENT OF RENIN, ACTH, AND PROSTAGLANDINS
INTERLEUKIN-1 STIMULATES ALDOSTERONE SECRETION - INVOLVEMENT OF RENIN, ACTH, AND PROSTAGLANDINS
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DOI：
10.1152/ajpregu.1992.263.4.r840
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发表时间：
1992-10-01
影响因子：
--
通讯作者：
BESEDOVSKY, HO
中科院分区：
文献类型：
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作者：
BATAILLARD, A;DELREY, A;BESEDOVSKY, HO
白细胞介素-1（IL-1），一种在感染和炎症过程中产生的细胞因子，介导了一些与这些过程平行的内分泌变化。本研究的目的是确定人重组IL-1（hrIL-1）是否影响醛固酮输出以及肾素和促肾上腺皮质激素（ACTH）的释放，这两个关键因素在调节盐皮质激素分泌。我们观察到，静脉注射hrIL-1到清醒的不受约束的大鼠引起了显着和迅速上升，血浆醛固酮水平的剂量依赖性的方式。hrIL-1诱导的醛固酮水平升高与血浆中肾素活性增强和ACTH水平升高相关。此外，IL-1注射大鼠的醛固酮水平与血浆肾素活性（PRA）呈正相关，表明肾素-血管紧张素系统有助于观察到的盐皮质激素水平的变化。ACTH似乎也牵连在醛固酮反应hrIL-1，因为在垂体激素和醛固酮水平的变化的动力学曲线的轮廓是相似的。用环氧合酶抑制剂吲哚美辛预处理显著降低了IL-1诱导的醛固酮血浆水平和PRA的增加，表明白藜芦醇参与了细胞因子的这些作用。这些结果表明，IL-1可能在感染性和炎症性疾病的稳态控制中发挥重要作用。
Interleukin-1 (IL-1), a cytokine produced during infection and inflammation, mediates some of the endocrinological alterations that parallel these processes. The purpose of this study was to determine whether human recombinant IL-1 (hrIL-1) affects aldosterone output as well as renin and adrenocorticotropic hormone (ACTH) release, two key factors in the regulation of mineralocorticoid secretion. We observed that intravenous administration of hrIL-1 into conscious unrestrained rats elicited a marked and rapid rise in aldosterone plasma levels in a dose-dependent manner. The hrIL-1-induced increase in aldosterone levels was associated with enhanced renin activity and increased ACTH levels in plasma. Furthermore, aldosterone levels of IL-1-injected rats were positively correlated with plasma renin activity (PRA), suggesting that the renin-angiotensin system contributes to the changes observed in the levels of the mineralocorticoid hormone. ACTH seems also to be implicated in the aldosterone response to hrIL-1 because the profile of the kinetic curves of changes in the levels of the pituitary hormone and aldosterone was similar. Pretreatment with the cyclooxygenase inhibitor indomethacin markedly reduced the increase in aldosterone plasma levels and PRA induced by IL-1, indicating that prostaglandins are involved in these effects of the cytokine. These results suggest that IL-1 may play an important role in the control of homeostasis during infectious and inflammatory diseases.