Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study
Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study
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中国女性反复自然流产病因学特征评价：单中心研究
DOI：
10.3760/cma.j.issn.0366-6999.2011.09.007
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发表时间：
2011-05-05
影响因子：
6.1
通讯作者：
Zhang Jian-ping
中科院分区：
文献类型：
--
作者：
Meng Li-li;Chen Hui;Zhang Jian-ping
背景已提出导致妊娠丢失的各种病因。尽管缺乏既定的和统一的筛查方法复发性流产（RPL），有几个因素被认为是明确的（或可能的）原因RPL。描述RPL病因学特征的数据几乎完全由高加索人群组成。由于我们感兴趣的是在中国的人口，本研究的目的是确定RPL的病因学特点，在中国patients.Methods这项研究进行了回顾性分析1122例妇女与RPL。根据流产次数将患者分为三组。诊断测试包括以下9项标准：父母遗传学、子宫解剖学、自身免疫因素、同种免疫因素、血栓形成因素、内分泌参数、生殖器感染、弓形虫、风疹、巨细胞病毒、疱疹（TORCH）滴度和RH血型。结果87.1%（977/1122）的患者有3项以上的异常，各组异常结果所占比例相似。除了父母遗传学、子宫解剖学和存在混合淋巴细胞反应阻断抗体（MLR-Bf）的情况外，各组之间的异常结果患病率没有差异。结论免疫功能紊乱在RPL的发病中起重要作用。中华医学杂志2011;124（9）：1310-1315
Background Various etiologies that contribute to the loss of pregnancy have been proposed. Despite the lack of established and uniform screening methods for recurrent pregnancy loss (RPL), there are several factors considered to be definite (or probable) causes of RPL. Data describing the etiological characteristics of RPL consist almost entirely of Caucasian populations. As we were interested in the Chinese population, the goal of this study was to determine the etiological characteristics of RPL in the Chinese patients.Methods The study was performed retrospectively by analyzing 1122 women with RPL. Patients were divided into three groups according to their number of pregnancy losses. Diagnostic tests included the following 9 critiria: parental genetics, uterine anatomy, autoimmune factors, alloimmune factors, thrombophilic factors, endocrine parameters, genital infection, toxoplasma, rubella, cytomegalovirus, herpes (TORCH) titers and RH blood groups. The criteria for abnormal results were defined before diagnosis.Results We found that 87.1% (977/1122) patients had no more than 3 abnormal aspects, and the proportion of total abnormal results was similar among groups. The prevalence of abnormal results for each test did not differ among groups, except in the cases of parental genetics, uterine anatomy and presence of mixed lymphocyte reaction blocking antibodies (MLR-Bf). Absence of MLR-Bf, as well as abnormally increased levels of CD3(+)CD19(+) and CD56(+)CD16(+) cells, was commonly detected in Chinese RPL patients.Conclusion Immunological disorders play an important role in RPL among Chinese patients. Chin Med J 2011;124(9):1310-1315