Molecular responses to hypoxia in tumor cells.
Molecular responses to hypoxia in tumor cells.
复制标题
分子对肿瘤细胞缺氧的反应。
DOI：
10.1186/1476-4598-2-23
复制
发表时间：
2003-04-17
期刊：
影响因子：
37.3
通讯作者：
Ibrahim, Saleh M
中科院分区：
文献类型：
--
作者：
Kunz, Manfred;Ibrahim, Saleh M
高度侵袭性、快速生长的肿瘤暴露于缺氧或甚至缺氧，这是由于血液供应不足而发生的。缺氧和连续缺氧/复氧对肿瘤细胞生物学产生多种影响。其中包括激活某些信号转导途径和基因调控机制，诱导基因突变的选择过程，肿瘤细胞凋亡和肿瘤血管生成。这些机制中的大多数有助于肿瘤进展。因此，组织缺氧被认为是肿瘤侵袭和转移的中心因素。本文从细胞内信号转导、基因调控、血管生成和细胞凋亡等方面综述了肿瘤细胞缺氧诱导的分子机制。干扰这些通路可能为未来高度侵袭性转移性肿瘤的创新治疗开辟前景。
Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology. Among these are activation of certain signal transduction pathways and gene regulatory mechanisms, induction of selection processes for gene mutations, tumor cell apoptosis and tumor angiogenesis. Most of these mechanisms contribute to tumor progression. Therefore, tissue hypoxia has been regarded as a central factor for tumor aggressiveness and metastasis. In this review, we summarize the current knowledge about the molecular mechanisms induced by tumor cell hypoxia with a special emphasis on intracellular signal transduction, gene regulation, angiogenesis and apoptosis. Interfering with these pathways might open perspectives for future innovative treatment of highly aggressive metastasizing tumors.