IGM, IGG AND IGA RHEUMATOID FACTORS (ANTIGLOBULINS) IN EARLY RHEUMATOID-ARTHRITIS AND THEIR PRODUCTION OF ARTICULAR INDEX OVER ONE YEAR
IGM, IGG AND IGA RHEUMATOID FACTORS (ANTIGLOBULINS) IN EARLY RHEUMATOID-ARTHRITIS AND THEIR PRODUCTION OF ARTICULAR INDEX OVER ONE YEAR
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DOI：
10.3109/03009748709165411
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发表时间：
1987-01-01
影响因子：
2.1
通讯作者：
HOLBOROW, EJ
中科院分区：
文献类型：
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作者：
MARCH, RE;KIRWAN, JR;HOLBOROW, EJ
应用酶联免疫吸附试验对33例新近确诊的类风湿关节炎患者进行了各类抗球蛋白(类风湿因子，RF)的检测，并对其进展情况进行了为期1年的3个月监测。对于RF，IgA-RF和IgM-RF的敏感性高于乳胶试验，其中一项或两项均为阳性，占76%。根据关节指数(AI)或血清C反应蛋白水平判断患者的临床状态与RF的任何一项指标之间均无相关性。对于个别患者，RF水平在不同评估之间有很大差异。对于超过1年的临床状态，最好的预测因子是初始AI和RF乳胶试验。虽然RF的类别特异性测量比乳胶试验更敏感，但个体患者体内个别类别的抗球蛋白随着时间的变化而对疾病进展的预测作用较小。
An enzyme-linked immunosorbent assay was used to detect antiglobulins (rheumatoid factors, RF) of various classes in 33 patients with recently diagnosed rheumatoid arthritis and to follow their progress with 3-monthly checks for 1 year. For RF, IgA-RF and IgM-RF showed greater sensitivity than the latex test, either or both being positive in 76%. There was no correlation between any of the measures of RF and patient''s clinical status as judged by articular index (AI), or serum CRP level. For individual patients, RF levels varied considerably between assessments. The best predictors of clinical status over 1 year were the initial AI and the latex test for RF. While class-specific measurement of RF is more sensitive than the latex test, the variation of individual classes of antiglobulins over time within individual patients makes them less helpful as predictors of disease progress.