EFFECTS OF TAXOL AND NOCODAZOLE ON INSULIN-SECRETION FROM ISOLATED RAT ISLETS OF LANGERHANS
EFFECTS OF TAXOL AND NOCODAZOLE ON INSULIN-SECRETION FROM ISOLATED RAT ISLETS OF LANGERHANS
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DOI：
10.1007/bf01114939
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发表时间：
1982-01-01
影响因子：
4
通讯作者：
TYHURST, M
中科院分区：
文献类型：
--
作者：
HOWELL, SL;HII, CS;TYHURST, M
紫杉醇是微管聚合的促进剂，诺可达唑是微管解聚的促进剂，它们在已知的浓度下对其他细胞类型的这些影响具有特异性，它们都抑制了葡萄糖刺激的大鼠朗格汉斯胰岛胰岛素的分泌。胰岛β细胞微管聚合-解聚的动态调节可能对通过微管-微丝系统分泌胰岛素具有重要意义。
Taxol, a promotor of microtubule polymerization, and nocodazole, which induces microtubule depolymerization, used at concentrations known to be specific for these effects in other cell types, each inhibited glucose-stimulated insulin secretion from isolated rat islets of Langerhans. The dynamic regulation of microtubule polymerization-depolymerization in pancreatic .beta.-cells may be important for insulin secretion via the microtubule-microfilamentous system.