Increased surface tension decreases pulmonary capillary volume and compliance.
Increased surface tension decreases pulmonary capillary volume and compliance.
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DOI：
10.1152/japplphysiol.00779.2001
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发表时间：
2002-09
影响因子：
3.3
通讯作者：
G. Topulos;Richard Brown;J. Butler
中科院分区：
文献类型：
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作者：
G. Topulos;Richard Brown;J. Butler
表面张力增加是几种呼吸系统疾病的重要组成部分，但其对肺毛细血管力学的影响还不完全清楚。我们测量了毛细血管体积和特定的顺应性之前和之后的表面张力与雾化硅氧烷在离体狗肺。表面张力的变化足以在50%总肺容量时增加肺回缩5 cm H2 O。增加表面张力降低毛细血管体积和特定的顺应性。毛细血管体积和顺应性的变化在表面张力变化最大的肺体积处最大。在接近功能残气量时，硅氧烷后毛细血管体积约为对照组的30%。Presiloxane毛细血管比顺应性约为7%/cm H2 O（接近功能残气量），约为2.5%/cm H2 O（接近总肺容量）。硅氧烷后毛细血管特异性顺应性为3%/cm H2 O，与肺容量无关。我们的结论是，除了对肺力学的众所周知的影响外，表面张力的变化也对毛细血管力学有重要影响。我们推测，这些变化可能反过来影响通气和灌注，恶化气体交换，并改变白细胞隔离。
Increased surface tension is an important component of several respiratory diseases, but its effects on pulmonary capillary mechanics are incompletely understood. We measured capillary volume and specific compliance before and after increasing surface tension with nebulized siloxane in excised dog lungs. The change in surface tension was sufficient to increase lung recoil 5 cm H(2)O at 50% total lung capacity. Increased surface tension decreased both capillary volume and specific compliance. The changes in capillary volume and compliance were greatest at the lung volumes at which the surface tension change was greatest. Near functional residual capacity, capillary volume postsiloxane was approximately 30% of control. Presiloxane capillary specific compliance was approximately 7%/cm H(2)O near functional residual capacity and approximately 2.5%/cm H(2)O near total lung capacity. Postsiloxane capillary-specific compliance was 3%/cm H(2)O, and was independent of lung volume. We conclude that in addition to their well-known effects on lung mechanics, changes in surface tension also have important effects on capillary mechanics. We speculate that these changes may in turn affect ventilation and perfusion, worsen gas exchange, and alter leukocyte sequestration.