The Nakalanga syndrome in Kabarole district, western Uganda
The Nakalanga syndrome in Kabarole district, western Uganda
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DOI：
10.4269/ajtmh.1996.54.80
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发表时间：
1996-01-01
影响因子：
3.3
通讯作者：
Leichsenring, M
中科院分区：
文献类型：
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作者：
Kipp, W;Burnham, G;Leichsenring, M
据报道，20世纪50年代和60年代在乌干达东部金贾附近的尼罗河沿岸出现了一种导致生长停滞的后天状况。这被称为Nakalanga侏儒症，并被认为与盘尾丝虫病有关。该地区在30多年前通过蚊幼虫控制盘尾丝虫病后，未发现新的病例。我们现在从乌干达西部报告这种情况，它的出现似乎是一个相对较近的事件。在卡巴罗尔区盘尾丝虫病高发地区，通过家庭调查确定了31名15岁及以上身材矮小的人。确定的病例与从最近的家庭中根据年龄和性别选择的对照相匹配。Nakalanga综合征患者的体重明显低于对照组，且比对照组短。年龄体重比、身高体重比、年龄身高比和身体质量指数的Z分数在病例中显著降低。在病例中观察到的其他临床特征包括没有第二性征、骨骼畸形、龋齿和智力迟钝。所有病例和22例（79%）对照在皮肤剪报中发现扭转盘尾丝虫微丝蚴。所有接受采访的社区成员都知道Nakalanga综合征，93%的人认为这是在出生后的某个时候获得的。讨论了与盘尾丝虫病的可能联系。
An acquired condition resulting in arrested growth was reported in the 1950s and 1960s from along the Nile near Jinja in eastern Uganda. This became known as Nakalanga dwarfism, and an association with onchocerciasis was postulated. After control of onchocerciasis through larvaciding in this area some 30 years ago, no new cases have been noted. We now report this condition from western Uganda where its appearance seems to be a relatively recently event. Thirty-one persons with short stature, 15 years of age and older, were identified through household surveys in an area of Kabarole district with a high prevalence of onchocerciasis. Cases identified were matched with controls selected for age and sex from the nearest household. Cases of Nakalanga syndrome weighed significantly less and were shorter than controls. The Z scores for weight-for-age, weight-for-height, height-for-age, and body mass index were significantly less among cases. Other clinical features observed among cases included absence of secondary sexual characteristics, skeletal deformities, dental caries, and mental retardation. All cases and 22 (79%) controls had microfilariae of Onchocerca volvulus in skin snips. All community members interviewed were aware of the Nakalanga syndrome, and 93% believed it to be acquired sometime after birth. The possible association with onchocerciasis is discussed.