Foveolar choroidal blood flow in age-related macular degeneration.
Foveolar choroidal blood flow in age-related macular degeneration.
复制标题
DOI：
--
复制
发表时间：
1998-02
影响因子：
4.4
通讯作者：
J. Grunwald;S. Hariprasad;J. Dupont;M. Maguire;S. Fine;A. Brucker;A. Maguire;A. Ho
中科院分区：
文献类型：
--
作者：
J. Grunwald;S. Hariprasad;J. Dupont;M. Maguire;S. Fine;A. Brucker;A. Maguire;A. Ho
目的比较非渗出型老年性黄斑变性(AMD)患者与正常对照组黄斑中心凹脉络膜血流的变化。方法用激光多普勒血流仪检测中心凹中心脉络膜相对血流速度(ChBVel)、血流量(ChBVol)和血流量(ChBFlow)。对20例(20只眼)有10个或10个以上的大玻璃体，视力为20/32或更高，无脉络膜新生血管的患者进行测量。将这些受试者的研究结果与10只年龄和血压匹配、没有大玻璃体的对照组受试者的10只眼睛进行比较。黄斑脉络膜血流量测量是通过让研究参与者盯着探测的激光光束来获得的。结果AMD患者的平均年龄、血压和眼压与正常对照组无显著差异。AMD患者的CHBVOL平均值为0.24+/-0.08(+/-1SD)任意单位(AU)，比对照组(0.36+/-0.11AU；双尾独立学生t检验，P=0.005)低33%。反之，AMD患者的平均ChBVel(0.44+/-0.10AU)与正常人(0.44+/-0.07AU)无显著差异。AMD组平均CHBFlow(8.7AU+/-3.1AU)较对照组(13.7AU+3.5AU)低37%(P=0.0005)。AMD组平均血流搏动指数(0.71+/-0.15)高于对照组(0.66+/-0.14)，但差异无统计学意义(P=0.42)。结论AMD非渗出期的平均ChBFlow低于年龄匹配的对照组，其主要原因是CHBVol降低。还需要进一步的研究来阐明ChBFlow降低是否在脉络膜新生血管的发展中起作用，以及ChBFlow测量是否有助于确定AMD患者是否存在发展脉络膜新生血管的风险。
PURPOSE To compare measurements of the foveolar choroidal blood circulation in subjects with nonexudative, age-related macular degeneration (AMD) with those of control subjects. METHODS Laser Doppler flowmetry was used to assess relative choroidal blood velocity (ChBVel), volume (ChBVol), and flow (ChBFlow) in the center of the fovea. Measurements were obtained in 20 eyes of 20 subjects with 10 or more large drusen, visual acuity of 20/32 or better, and no evidence of choroidal neovascularization. Findings obtained in these subjects were compared with those of 10 eyes of 10 age- and blood pressure-matched control subjects with no large drusen. Foveolar choroidal blood flow measurements were obtained by asking the study participants to fixate on a probing laser beam. RESULTS No significant differences in average age, blood pressure, or intraocular pressure were observed between subjects with AMD and control subjects. In subjects with AMD, average ChBVol was 0.24 +/- 0.08 (+/- 1 SD) arbitrary units (AU); this value was 33% lower than that of control subjects (0.36 +/- 0.11 AU; two-tailed, independent Student's t-test, P = 0.005). Average ChBVel, conversely, was not significantly different from normal (0.44 +/- 0.07 AU) in subjects with AMD (0.44 +/- 0.10 AU). Average ChBFlow in subjects with AMD (8.7 +/- 3.1 AU) was 37% lower than that of control subjects (13.7 +/- 3.5 AU) (P = 0.0005). Average blood flow pulsatility was 6% higher in subjects with AMD (0.71 +/- 0.15) than in control subjects (0.66 +/- 0.14), but this difference was not statistically significant (P = 0.42). CONCLUSIONS Average ChBFlow in the nonexudative stages of AMD is lower than that of age-matched controls, and the effect is caused mainly by a decrease in ChBVol. Further studies are needed to elucidate whether decreased ChBFlow plays a role in the development of choroidal neovascularization, and whether ChBFlow measurements may help identify subjects with AMD at risk for developing choroidal neovascularization.