Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta
Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta
复制标题
DOI：
10.1248/cpb.49.1372
复制
发表时间：
2001-10-01
影响因子：
1.7
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Aoki, S;Ye, Y;Kobayashi, M
从海绵Hyrtios erecta中分离得到两个新的aplysinopsin型吲哚生物碱1和2，以及三个已知的吲哚生物碱。这些化合物对一氧化氮合酶（nNOS）的神经元同工酶表现出选择性抑制活性。此外，还从该海绵中分离到一个新的喹诺酮7。通过波谱分析确定了新化合物的化学结构。
Two novel aplysinopsin-type indole alkaloids, 1 and 2, and three known indole alkaloids were isolated from the marine sponge Hyrtios erecta. These compounds exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase (nNOS). Furthermore, new quinolone 7 was also isolated from the same marine sponge. The chemical structures of these new compounds were elucidated on the basis of spectroscopic analysis.